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EGFR — PDLIM7
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wang et al., Zhonghua Zhong Liu Za Zhi 2001
(Nasopharyngeal Neoplasms) :
Stable expression of
LMP1 in HNE2 cells
increased the expression of
EGFR
Tao et al., Cell Signal 2004
:
LMP1 increases the levels of both
EGFR protein and mRNA, but does not stabilize EGFR mRNA ... In this study, induction of
LMP1 increased the
EGFR in both protein and promoter levels in a dose dependent manner using tetracycline regulated LMP1 expression in nasopharyngeal carcinoma (NPC) cell line ... Promoter mutagenesis analysis demonstrated that two putative NFkappaB binding sites of EGFR promoter were very necessary for the transcriptional activity of
EGFR induced by
LMP1 , the proximal NFkappaB binding site was more important than the distal NFkappaB binding site, and both NFkappaB binding sites played a cooperative role
Tao et al., Virus Res 2004
:
LMP1 increases the levels of both
EGFR protein and mRNA but does not stabilize EGFR mRNA ... In this study, induction of
LMP1 increased the
EGFR in both protein and promoter levels in a dose dependent manner using tetracycline regulated LMP1 expression in nasopharyngeal carcinoma (NPC) cell line ... Promoter mutagenesis analysis demonstrated that two putative NFkappaB binding sites of EGFR promoter were very necessary for the transcriptional activity of
EGFR induced by
LMP1 , the proximal NFkappaB binding site was more important than the distal NFkappaB binding site
Tao et al., Sci China C Life Sci 2004
:
We found that
LMP1 could
regulate the nuclear translocation of
EGFR in a dose dependent manner from both quantitative and qualitative levels through the Western blot analysis and the immunofluorescent analysis with a laser scanning confocal microscope ... We further demonstrated that the nuclear localization sequence of EGFR played some roles in the location of the protein within the nucleus under LMP1 regulation, and the nuclear accumulation of
EGFR regulated by
LMP1 was in a ligand independent manner
Tao et al., Exp Cell Res 2005
(Epstein-Barr Virus Infections...) :
We found that
LMP1 could
regulate the nuclear accumulation of
EGFR in a dose dependent manner quantitatively and qualitatively
Charalambous et al., Carcinogenesis 2007
(Neoplasms) :
Epidermal growth factor receptor (EGFR) ligands ( transforming growth factor alpha ( TGFalpha ), heparin binding EGF-like growth factor and epiregulin ) are constitutively
induced by
LMP1 , leading to EGFR phosphorylation but also down-regulation, degradation or turn-over, with the appearance of cleaved EGFR fragments
Thornburg et al., J Virol 2007
:
In this study, the role of NF-kappaB p50 and Bcl-3 in
LMP1 mediated upregulation of
EGFR was analyzed ... These data suggest that induction of p50/p50/Bcl-3 complexes by LMP1 CTAR1 mediates
LMP1 induced
EGFR upregulation and that formation of the p50/p50/Bcl-3 complex is negatively regulated by the p105 precursor
Kung et al., J Virol 2011
:
Epstein-Barr virus
LMP1 activates
EGFR , STAT3, and ERK through effects on PKCdelta ...
EGFR transcription is
induced by
LMP1 through a p50 NF?B1-Bcl-3 complex, and Bcl-3 is induced by LMP1 mediated activation of STAT3 ... Upon treatment with EGF, the
LMP1-CTAR1 induced
EGFR was additionally phosphorylated and STAT3 became phosphorylated on tyrosine, concomitant with upregulation of a subset of STAT3 target genes
Miller et al., J Virol 1995
(Nasopharyngeal Neoplasms) :
Stable or transient expression of
LMP1 in C33A cells
increased expression of the
EGFR at both the protein and mRNA levels ... In contrast, expression of the
EGFR was not
induced by
LMP1 in EBV infected B lymphocytes ... Stimulation of LMP1 expressing C33A cells with epidermal growth factor (EGF) caused rapid tyrosine phosphorylation of the EGFR ( pp170 ) as well as several other proteins, including pp120, pp85, pp75, and pp55, indicating that the
EGFR induced by
LMP1 is functional ... The
induction of
EGFR and A20 by
LMP1 may be an important component of EBV infection in epithelial cells and could contribute to the development of epithelial malignancies such as NPC
Miller et al., J Virol 1997
:
Epstein-Barr virus
LMP1 induction of the
epidermal growth factor receptor is mediated through a TRAF signaling pathway distinct from NF-kappaB activation ... These results indicate that
induction of the
EGFR by
LMP1 involves the TRAF interaction domain and that activation of NF-kappaB alone is not sufficient ... These data further define the mechanism by which
LMP1 induces expression of the
EGFR and indicate that TRAF signaling from LMP1 and CD40 activates a downstream transcription pathway distinct from NF-kappaB that induces expression of the EGFR
Miller et al., Mol Cell Biol 1998
:
However, exogenous expression of TRAF3 decreased
EGFR induction
mediated by either
LMP1 or CD40
Miller et al., Oncogene 1998
(Nasopharyngeal Neoplasms) :
In addition,
LMP1 engages the TRAF signaling pathway
resulting in the induction of
EGFR expression