Gene interactions and pathways from curated databases and text-mining

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PDLIM7 — SMAD6

Text-mined interactions from Literome

Prokova et al., J Biol Chem 2002 (Cell Transformation, Neoplastic) : LMP1 strongly inhibited the uninduced and the Smad-inducible activity of the promoters of the human p21/WAF1/Cip1 gene and the mouse Smad7 gene ... Inhibition of TGFbeta signaling and Smad dependent activation of transcription by LMP1 was greatly reduced by deletion of both C-terminal activating regions 1 and 2 of LMP1 as well as by overexpression of a non-degradable form of IkappaB
Tzimas et al., Cell Signal 2006 : Overexpression of USP31 in HEK 293T cells inhibited TNFalpha, CD40, LMP1 , TRAF2, TRAF6 and IKKbeta mediated NF-kappaB activation, but did not inhibit Smad mediated transcription activation