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FOXO3 — PGC

Text-mined interactions from Literome

Geng et al., Am J Pathol 2011 (Cachexia) : PGC-1a promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in mice
Chung et al., Nephrol Dial Transplant 2012 (Kidney Diseases) : Interestingly, administering fenofibrate or tempol to the HFD induced SHRs reversed all of the renal phenotypes by increasing the PPARa expression with concomitant inactivation of the PI3K-Akt pathway, dephosphorylation of FoxO3a and activation of PGC-1a-ERR-1a signaling, and this all resulted in ameliorating the oxidative stress and apoptotic cell death