Gene interactions and pathways from curated databases and text-mining

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PGF — STAT3

Pathways - manually collected, often from reviews:

  • KEGG Pathways in cancer: STAT3 → FIGF/PGF/VEGFA/VEGFB/VEGFC (gene expression, expression)
  • KEGG Pancreatic cancer: STAT3 → FIGF/PGF/VEGFA/VEGFB/VEGFC (gene expression, expression)

Text-mined interactions from Literome

Bellik et al., Br J Pharmacol 2005 : In cultured rat VSMCs exposed to hypoxia, PlGF increased the phosphorylation of protein kinase B ( Akt ), p38 and STAT3 ; activation of STAT3 was higher than that of other kinases
Chen et al., Cancer Biol Ther 2008 (Neoplasms...) : FGF2 but not PlGF also induced EC STAT3 activation in vitro