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CYP1A1 — PHIP

Text-mined interactions from Literome

Yamazaki et al., Mutat Res 2004 : CYP1A1 and CYP1A2 were responsible for the mutagenic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-acetylaminofluorene
Ma et al., Carcinogenesis 2007 : However, the role of CYP1A1 in PhIP metabolic activation in vivo is unclear ... In this study, Cyp1a1-null and wild-type ( WT ) mice were used to investigate the potential role of CYP1A1 in PhIP metabolic activation in vivo
Bendaly et al., Xenobiotica 2009 : These results strongly support activation of PhIP by CYP1A1 with little effect of human NAT2 genetic polymorphism on mutagenesis and DNA damage