Gene interactions and pathways from curated databases and text-mining

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GYS2 — PHKG2

Pathways - manually collected, often from reviews:

  • WikiPathways Glycogen Metabolism: PHKA1/PHKA2/PHKB/PHKG1/PHKG2/CALM2/CALM2/CALM2 → GYS1/GYS2 (inhibition)

Text-mined interactions from Literome

Bode et al., Mol Cell Biochem 1988 : Isoproterenol and prostaglandin E1 both stimulate cAMP accumulation, but only isoproterenol causes activation of particulate cAMP dependent protein kinase, leading to activation of phosphorylase kinase and glycogen phosphorylase, and inhibition of glycogen synthase
Picton et al., Cell Calcium 1981 : Recent work has demonstrated that phosphorylase kinase not only activates phosphorylase, but also phosphorylates glycogen synthase thereby decreasing its activity ( 45-49 )