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PI3 — SOAT1
Text-mined interactions from Literome
Song et al., Chin J Cancer 2002
(Multiple Myeloma) :
IL-6 inhibited apoptosis of XG-7 cells through up-regulation of Mcl-1 and the
activation of
JAK/STAT rather than Ras/MAPK nor
PI-3K/Akt signal transduction pathway
Dhar-Mascareno et al., Biochem Biophys Res Commun 2005
:
Furthermore, inhibition of
PI3-kinase activity also abrogated GM-CSF
induced Stat activation
Hongo et al., Am J Physiol Endocrinol Metab 2009
:
The enhanced expression of
ACAT-1 protein by leptin was
suppressed by inhibitors of Janus activated kinase2 (JAK2) and
phosphatidylinositol 3-kinase (PI3K)
Beyer et al., PLoS Comput Biol 2011
:
For IL-2R signaling, we show that
STAT activation is
independent of both Src- and
PI3-kinases , while ERK activation depends upon both kinases and additionally requires novel PKCs
Coffer et al., Oncogene 1997
:
Furthermore, although previous studies have suggested a
role for MAP kinases ( ERKs ) and
PI-3K in
STAT activation, utilising the specific MEK inhibitor PD098059 and the PI-3K inhibitor wortmannin, we demonstrate that activation of ERKs or PI-3K are not required for insulin induced Stat3 phosphorylation or transactivation