Gene interactions and pathways from curated databases and text-mining

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MDM2 — PIK3CA

Text-mined interactions from Literome

Skinner et al., J Biol Chem 2004 (Ovarian Neoplasms) : The inhibition of PI3K by LY294002 inhibited p70S6K1 and HDM2 activity in the cells
Du et al., PloS one 2013 (Neoplasms) : In this study, we show that IGF-1 up-regulates MDM2 protein levels in a PI3K/AKT dependent manner