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HSPG2 — PIP
Text-mined interactions from Literome
Wellner-Kienitz et al., Biochim Biophys Acta 2003
:
This inhibition is supposed to be mediated via a G ( q/11 )
-PLC mediated depletion of
PIP2 , suggesting a partial coupling of overexpressed H2-R to G ( q/11 )
Homma et al., Biochem Biophys Res Commun 1992
:
We determined the effect of purified rP45Z or rP38Z on PIP2 hydrolyzing activity of either PLC-gamma 1 or PLC-gamma 2 and found that these proteins strongly suppressed the rate of
PLC dependent
PIP2-hydrolysis
Banno et al., J Biol Chem 1992
:
These results suggested that the inhibition of
PLC by gelsolin is
due to sequestration of substrate
PIP2 by its competitive binding
van Rheenen et al., J Cell Biol 2007
(Breast Neoplasms...) :
We show that EGF
induces a rapid loss of
PIP ( 2 ) through
PLC activity, resulting in a release and activation of a membrane bound pool of cofilin
Kwon et al., FEBS Lett 2009
:
Collectively, these data suggest that syndecan-4 promotes plasma membrane retention of PIP ( 2 ) by negatively regulating
PLC dependent
PIP ( 2 ) degradation
Hernandez et al., J Gen Physiol 2009
:
We then constructed a cellular model that incorporates
PLC activation by oxo-M, PIP ( 2 ) hydrolysis,
PIP ( 2 ) binding to Kv7-channel subunits, and K ( + ) current through Kv7 tetramers