Gene interactions and pathways from curated databases and text-mining

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HSPG2 — PIP

Text-mined interactions from Literome

Wellner-Kienitz et al., Biochim Biophys Acta 2003 : This inhibition is supposed to be mediated via a G ( q/11 ) -PLC mediated depletion of PIP2 , suggesting a partial coupling of overexpressed H2-R to G ( q/11 )
Homma et al., Biochem Biophys Res Commun 1992 : We determined the effect of purified rP45Z or rP38Z on PIP2 hydrolyzing activity of either PLC-gamma 1 or PLC-gamma 2 and found that these proteins strongly suppressed the rate of PLC dependent PIP2-hydrolysis
Banno et al., J Biol Chem 1992 : These results suggested that the inhibition of PLC by gelsolin is due to sequestration of substrate PIP2 by its competitive binding
van Rheenen et al., J Cell Biol 2007 (Breast Neoplasms...) : We show that EGF induces a rapid loss of PIP ( 2 ) through PLC activity, resulting in a release and activation of a membrane bound pool of cofilin
Kwon et al., FEBS Lett 2009 : Collectively, these data suggest that syndecan-4 promotes plasma membrane retention of PIP ( 2 ) by negatively regulating PLC dependent PIP ( 2 ) degradation
Hernandez et al., J Gen Physiol 2009 : We then constructed a cellular model that incorporates PLC activation by oxo-M, PIP ( 2 ) hydrolysis, PIP ( 2 ) binding to Kv7-channel subunits, and K ( + ) current through Kv7 tetramers