◀ Back to PI3

PI3 — PIP

Text-mined interactions from Literome

Farese et al., Experimental biology and medicine (Maywood, N.J.) 2001 : These changes include : ( i ) activation of phosphatidylinositol 3-kinase (PI3K) and production of PIP3 ; ( ii ) PIP3 dependent activation of atypical protein kinase Cs ( PKCs ) ; ( iii ) PIP3 dependent activation of PKB ; ( iv ) PI3K dependent activation of phospholipase D and hydrolysis of phosphatidylcholine with subsequent increases in phosphatidic acid ( PA ) and diacylglycerol ( DAG ) ; ( v ) PI3K independent activation of glycerol-3-phosphate acylytansferase and increases in de novo synthesis of PA and DAG ; and ( vi ) activation of DAG-sensitive PKCs
Suire et al., EMBO J 2012 : The genetic loss of RasGRP4 phenocopies knock-in of a Ras-insensitive version of PI3Kc in its effects on PI3Kc dependent PIP3 accumulation, PKB activation, chemokinesis and reactive oxygen species ( ROS ) formation