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LPA — PLD2
Text-mined interactions from Literome
Das et al., Thyroid 1999
:
To determine whether
PLD activation
mediated the effects of
LPA , PLD activity was examined in FRTL-5 thyroid cells 30 minutes after LPA exposure
Shin et al., Mol Cells 1999
:
The C3 toxin, which inhibited stress fiber formation stimulated by LPA, blocked the H2O2 production in response to LPA or PA, but had no inhibitory effect on the
activation of
PLD by
LPA
Hess et al., Cell Signal 2000
:
Lysophosphatidic acid (LPA) and endothelin-1 (ET-1)
activate phospholipase D ( PLD ) in many cell types ... In summary, these results show that the altered
PLD responses to
LPA and ET-1 in PLCgamma1-/- are due to changes in PLC activity and do not involve tyrosine kinase activity
Eder et al., Clin Cancer Res 2000
(Breast Neoplasms...) :
Constitutive and lysophosphatidic acid (LPA) induced
LPA production :
role of
phospholipase D and phospholipase A2 ... We show that
phospholipase D activity
contributes to both constitutive and LPA induced
LPA production by ovarian cancer cells
Wang et al., J Biol Chem 2003
:
LPA activated both PLD1 and
PLD2 in HBEpCs ; however, infection of cells with cDNA for wild type PLD2, but not PLD1, increased the tyrosine phosphorylation of PDGF-R beta in response to LPA
Kam et al., FASEB J 2004
:
LPA caused much less phosphorylation of Akt and this was
dependent on
PLD activity
Tou et al., Cell Signal 2005
:
Several studies have shown that
LPA stimulates
phospholipase D ( PLD ) activity in fibroblasts and prostate cancer cells in culture ... In the present study, we examined the
effect of
LPA on
PLD activity and degranulation by human neutrophils ... The results show that exogenous
LPA increased PA formation,
PLD activity and degranulation by human neutrophils in a time and concentration dependent manner
van der Bend et al., Biochem J 1992
:
Our results indicate that : ( 1 ) LPA is less efficient than endothelin in inducing phosphoinositide and PC breakdown ; ( 2 )
LPA induced
PLD activation is short lived, levelling off after 2 min, whereas the endothelin stimulated increase in PLD activity persists for at least 1 h ; ( 3 ) the effect of LPA on PLD, like that of endothelin, is blocked by long-term pretreatment of the cells with phorbol ester, suggesting that PLD activation occurs through a protein kinase C-dependent mechanism
Gayral et al., Circ Res 2006
:
In addition,
lysophosphatidic acid (LPA) or angiotensin II treatment of VSMCs
resulted in an increase of intranuclear
PLD activity, whereas platelet derived growth factor and epidermal growth factor have no significant effect
Pilquil et al., J Biol Chem 2006
:
Consistent with this conclusion, LPP1 expression decreased
phospholipase D ( PLD ) stimulation by
LPA and PDGF, and phosphatidate accumulation ... However, ERK and Rho activation were not downstream targets of
LPA induced
PLD(2) activity
Gibbs et al., Prostate 2009
(Prostatic Neoplasms) :
LPA and S1P
stimulate phospholipase D ( PLD ) activity to varying extents in the different cell lines ... In Du145,
LPA , but not S1P,
activates PLD and enhances cellular production of LPA
Snider et al., Am J Physiol Cell Physiol 2010
(Ovarian Neoplasms) :
This study explores the
role of
phospholipase D2 (PLD2) activation in
LPA production, as well as cross-talk between EGF and LPA receptors ... Overexpression of PLD2 increases LPA production, while knockdown of
PLD2 blocks EGF induced
LPA production
Malcolm et al., J Biol Chem 1996
:
Neither the time course nor agonist dose response for
LPA stimulated
PLD activity was altered in C3-treated cells ... However, disruption of actin filaments with cytochalasin D caused only a minor inhibition of
LPA stimulated
PLD activity
Cross et al., Curr Biol 1996
:
We report that, in porcine aortic endothelial ( PAE ) cells,
lysophosphatidic acid (LPA) stimulated
PLD activity and rapidly generated PA in the absence of other phospholipase, PI 3-kinase or MAP kinase activities
Qi et al., J Cell Physiol 1998
(Prostatic Neoplasms) :
The
effects of
LPA on
PLD activity and proliferation were examined in PC-3 cells, which express hPLD1a/1b ...
LPA induced a transient activation of
PLD that was maximal by 10 minutes ... The EC50 for
LPA induced
PLD activation was approximately 1 microM ... Pertussis toxin did not inhibit
activation of
PLD by
LPA or PMA ... Ro-31-8220 and bisindolylmaleimide I, inhibitors of protein kinase C, blocked
activation by
PLD by both PMA and
LPA ... Perillyl alcohol, an anti-cancer drug, reversibly inhibited proliferation in response to either serum or LPA but did not inhibit
activation of
PLD by PMA or
LPA ... These data establish that
LPA activates
PLD and stimulates proliferation via Gi-independent pathways in a human prostate cancer cell line