Gene interactions and pathways from curated databases and text-mining

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LPA — PLD2

Text-mined interactions from Literome

Das et al., Thyroid 1999 : To determine whether PLD activation mediated the effects of LPA , PLD activity was examined in FRTL-5 thyroid cells 30 minutes after LPA exposure
Shin et al., Mol Cells 1999 : The C3 toxin, which inhibited stress fiber formation stimulated by LPA, blocked the H2O2 production in response to LPA or PA, but had no inhibitory effect on the activation of PLD by LPA
Hess et al., Cell Signal 2000 : Lysophosphatidic acid (LPA) and endothelin-1 (ET-1) activate phospholipase D ( PLD ) in many cell types ... In summary, these results show that the altered PLD responses to LPA and ET-1 in PLCgamma1-/- are due to changes in PLC activity and do not involve tyrosine kinase activity
Eder et al., Clin Cancer Res 2000 (Breast Neoplasms...) : Constitutive and lysophosphatidic acid (LPA) induced LPA production : role of phospholipase D and phospholipase A2 ... We show that phospholipase D activity contributes to both constitutive and LPA induced LPA production by ovarian cancer cells
Wang et al., J Biol Chem 2003 : LPA activated both PLD1 and PLD2 in HBEpCs ; however, infection of cells with cDNA for wild type PLD2, but not PLD1, increased the tyrosine phosphorylation of PDGF-R beta in response to LPA
Kam et al., FASEB J 2004 : LPA caused much less phosphorylation of Akt and this was dependent on PLD activity
Tou et al., Cell Signal 2005 : Several studies have shown that LPA stimulates phospholipase D ( PLD ) activity in fibroblasts and prostate cancer cells in culture ... In the present study, we examined the effect of LPA on PLD activity and degranulation by human neutrophils ... The results show that exogenous LPA increased PA formation, PLD activity and degranulation by human neutrophils in a time and concentration dependent manner
van der Bend et al., Biochem J 1992 : Our results indicate that : ( 1 ) LPA is less efficient than endothelin in inducing phosphoinositide and PC breakdown ; ( 2 ) LPA induced PLD activation is short lived, levelling off after 2 min, whereas the endothelin stimulated increase in PLD activity persists for at least 1 h ; ( 3 ) the effect of LPA on PLD, like that of endothelin, is blocked by long-term pretreatment of the cells with phorbol ester, suggesting that PLD activation occurs through a protein kinase C-dependent mechanism
Gayral et al., Circ Res 2006 : In addition, lysophosphatidic acid (LPA) or angiotensin II treatment of VSMCs resulted in an increase of intranuclear PLD activity, whereas platelet derived growth factor and epidermal growth factor have no significant effect
Pilquil et al., J Biol Chem 2006 : Consistent with this conclusion, LPP1 expression decreased phospholipase D ( PLD ) stimulation by LPA and PDGF, and phosphatidate accumulation ... However, ERK and Rho activation were not downstream targets of LPA induced PLD(2) activity
Gibbs et al., Prostate 2009 (Prostatic Neoplasms) : LPA and S1P stimulate phospholipase D ( PLD ) activity to varying extents in the different cell lines ... In Du145, LPA , but not S1P, activates PLD and enhances cellular production of LPA
Snider et al., Am J Physiol Cell Physiol 2010 (Ovarian Neoplasms) : This study explores the role of phospholipase D2 (PLD2) activation in LPA production, as well as cross-talk between EGF and LPA receptors ... Overexpression of PLD2 increases LPA production, while knockdown of PLD2 blocks EGF induced LPA production
Malcolm et al., J Biol Chem 1996 : Neither the time course nor agonist dose response for LPA stimulated PLD activity was altered in C3-treated cells ... However, disruption of actin filaments with cytochalasin D caused only a minor inhibition of LPA stimulated PLD activity
Cross et al., Curr Biol 1996 : We report that, in porcine aortic endothelial ( PAE ) cells, lysophosphatidic acid (LPA) stimulated PLD activity and rapidly generated PA in the absence of other phospholipase, PI 3-kinase or MAP kinase activities
Qi et al., J Cell Physiol 1998 (Prostatic Neoplasms) : The effects of LPA on PLD activity and proliferation were examined in PC-3 cells, which express hPLD1a/1b ... LPA induced a transient activation of PLD that was maximal by 10 minutes ... The EC50 for LPA induced PLD activation was approximately 1 microM ... Pertussis toxin did not inhibit activation of PLD by LPA or PMA ... Ro-31-8220 and bisindolylmaleimide I, inhibitors of protein kinase C, blocked activation by PLD by both PMA and LPA ... Perillyl alcohol, an anti-cancer drug, reversibly inhibited proliferation in response to either serum or LPA but did not inhibit activation of PLD by PMA or LPA ... These data establish that LPA activates PLD and stimulates proliferation via Gi-independent pathways in a human prostate cancer cell line