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GP6 — PLG

Text-mined interactions from Literome

Deli et al., Eur J Pharmacol 2001 : Tissue plasminogen activator inhibits P-glycoprotein activity in brain endothelial cells ... Tissue plasminogen activator ( 0.01-30 microgram/ml ) dose-dependently inhibited the functional activity of P-glycoprotein , assessed by rhodamine 123 accumulation in GP8 immortalized rat brain endothelial cells, but this effect was unrelated to its proteolytic activity
Koschnick et al., Journal of thrombosis and haemostasis : JTH 2005 (Thrombosis) : The role of vitronectin (VN) in thrombosis is not fully understood, primarily because this adhesive glycoprotein not only stabilizes plasminogen activator inhibitor 1 ( PAI-1 ) and thus protects fibrin from premature lysis, but also because it binds to platelet integrins and may influence platelet aggregation
Bogenmann et al., J Natl Cancer Inst 1983 (Fibrosarcoma...) : HT-1080 cells digested the matrices in a density dependent manner, and while matrix glycoprotein degradation was plasminogen dependent at the beginning of the experiment and at low cell densities, the zymogen was not essential for further glycoprotein digestion at high cell densities
de Haan et al., Thromb Res 1998 : Platelets and soluble fibrin promote plasminogen activation causing downregulation of platelet glycoprotein Ib/IX complexes : protection by aprotinin ... The plasmin generation resulted in a downregulation of platelet membrane glycoprotein Ib/IX glycoprotein complexes