◀ Back to RHOA
PLXNB1 — RHOA
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
RHOA
→
Complex of ARHGEF12-PLXNB1
(directlyIncreases, ARHGEF12/PLXNB1 Activity)
Swiercz et al., J Cell Biol 2004
Evidence: Plexin-B1 has recently been shown to mediate activation of RhoA through a stable interaction with the Rho guanine nucleotide exchange factors PDZ-RhoGEF and LARG.
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OpenBEL Selventa BEL large corpus:
RHOA
→
PLXNB1
(increases, PLXNB1 Activity)
Swiercz et al., J Cell Biol 2004
Evidence: Our data indicate that ErbB-2 is an important component of the plexin-B receptor system and that ErbB-2-mediated phosphorylation of plexin-B1 is critically involved in Sema4D-induced RhoA activation, which underlies cellular phenomena downstream of plexin-B1, including axonal growth cone collapse.
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Reactome Reaction:
RHOA
→
PLXNB1
(reaction)
Hirotani et al., Biochem Biophys Res Commun 2002, Oinuma et al., J Biol Chem 2003, Swiercz et al., J Cell Biol 2004, Barberis et al., J Cell Sci 2005*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Aurandt et al., Proc Natl Acad Sci U S A 2002
:
Semaphorin 4D is the ligand for the plexin-B1 receptor and stimulation of the
plexin-B1 receptor
activates the small GTPase
RhoA
Oinuma et al., J Biol Chem 2003
:
Recent studies have demonstrated that
Plexin-B1 activates
RhoA and induces growth cone collapse through Rho-specific guanine nucleotide exchange factor PDZ-RhoGEF ... We also found that Rnd1 promoted the interaction between Plexin-B1 and PDZ-RhoGEF and thereby dramatically potentiated the
Plexin-B1 mediated
RhoA activation
Swiercz et al., J Cell Biol 2004
:
Plexin-B1/RhoGEF mediated
RhoA activation involves the receptor tyrosine kinase ErbB-2 ... Our data indicate that ErbB-2 is an important component of the plexin-B receptor system and that ErbB-2 mediated phosphorylation of
plexin-B1 is critically
involved in Sema4D induced
RhoA activation, which underlies cellular phenomena downstream of plexin-B1, including axonal growth cone collapse
Aurandt et al., Biochem J 2006
(MAP Kinase Signaling System) :
We have found that the mechanism of activation requires the C-terminus of
plexin-B1 and the
activation of
RhoA
Swiercz et al., Mol Cell Biol 2009
:
The semaphorin 4D (Sema4D) receptor
plexin-B1 constitutively interacts with particular Rho guanine nucleotide exchange factors ( RhoGEFs ) and thereby
mediates Sema4D induced
RhoA activation, a process which involves the tyrosine phosphorylation of plexin-B1 by ErbB-2
Negishi-Koga et al., Nat Med 2011
(Bone Resorption...) :
The binding of Sema4D to its receptor
Plexin-B1 on osteoblasts
resulted in the activation of the small GTPase
RhoA , which inhibits bone formation by suppressing insulin-like growth factor-1 (IGF-1) signaling and by modulating osteoblast motility