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BAX — POU4F1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Direct p53 effectors: POU4F1 (POU4F1) → BAX (BAX) (transcription, inhibits) Shikama et al., Mol Cell 1999, Thornborrow et al., J Biol Chem 2001, Thornborrow et al., Oncogene 2002, Hudson et al., J Biol Chem 2005, Sykes et al., Mol Cell 2006
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Direct p53 effectors: POU4F1 (POU4F1) → BAX (BAX) (transcription, inhibits) Thornborrow et al., J Biol Chem 2001, Thornborrow et al., Oncogene 2002, Hudson et al., J Biol Chem 2005, Budhram-Mahadeo et al., Nucleic Acids Res 2006*, Sykes et al., Mol Cell 2006
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Direct p53 effectors: POU4F1 (POU4F1) → BAX (BAX) (transcription, inhibits) Thornborrow et al., J Biol Chem 2001, Samuels-Lev et al., Mol Cell 2001, Thornborrow et al., Oncogene 2002, Hudson et al., J Biol Chem 2005, Sykes et al., Mol Cell 2006
  Evidence: mutant phenotype, reporter gene, physical interaction

Text-mined interactions from Literome

Perez-Sanchez et al., Nucleic Acids Res 2002 : Thus, Brn-3a inhibits activation of the Bax promoter by p53 but enhances the ability of p53 to activate the p21 promoter
Budhram-Mahadeo et al., Nucleic Acids Res 2006 : However, whereas Brn-3a repressed p53 mediated Bax expression but cooperated with p53 to increase p21cip1/waf1, this study demonstrated that co-expression of Brn-3b with p53 increases trans-activation of Bax promoter but not p21cip1/waf1