Gene interactions and pathways from curated databases and text-mining

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JUN — PPARG

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Uchimura et al., Hepatology 2001 : PPAR gamma:RXR activation also did not affect nuclear factor kappa B (NF-kappa B) nuclear translocation nor NF-kappa B and activator protein 1 (AP-1) activation in the electrophoretic mobility-shift assay
Fahmi et al., Arthritis Rheum 2001 : Similarly, in a PPARgamma dependent manner, 15d-PGJ2 inhibited deltaMEKK-1 induced AP-1- and NF-kappaB-luciferase reporter plasmid activation
Subbaramaiah et al., J Biol Chem 2001 (Arthritis...) : The induction of c-Jun by PMA was blocked by PPARgamma ligands
Wang et al., J Biol Chem 2002 (Inflammation) : Furthermore, constitutive activation of PPAR-gamma resulted in simultaneous repression of AP-1 and NF-kappaB activity, which suggests that PPAR-gamma may reduce pro-inflammatory phenotypes via, at least in part, suppression of the AP-1 and NF-kappaB pathways
Salomonsson et al., Atherosclerosis 2003 : Together, these data suggest that oxLDL decreases VEGFR-1 expression in macrophages, probably through a PPARgamma dependent reduction in the AP-1 transcriptional activity
Guo et al., Diabetes 2004 : PPAR-gamma overexpression inhibited TGF-beta 1-induced fibronectin expression as well as the activation of AP-1 ... In conclusion, pioglitazone inhibits TGF-beta 1-induced fibronectin expression by inhibiting AP-1 activation dependent on PPAR-gamma , while 15d-PGJ ( 2 ) acts through a dual mechanism independent of and dependent on PPAR-gamma activation in mouse mesangial cells
Hazra et al., J Biol Chem 2004 : PPARgamma expression also inhibits the activation markers such as the expression of alpha-smooth muscle actin, type I collagen, and transforming growth factor beta1 ; DNA synthesis ; and JunD binding to the activator protein-1 (AP-1) site and AP-1 promoter activity
Konstantinopoulos et al., Int J Colorectal Dis 2007 (Adenocarcinoma...) : Down-regulation of PPAR gamma and induction of the CBP transcriptional coactivator can augment NF-kappaB and AP-1 transcriptional activities leading to up-regulation of COX-2 expression in colon adenocarcinoma cells
Dai et al., J Dermatol Sci 2008 : These results suggest that PPAR gamma regulates involucrin expression by controlling the AP-1 signal and p38 activation in 1 alpha,25 ( OH ) 2D3 induced keratinocyte differentiation
Riek et al., J Steroid Biochem Mol Biol 2010 (Atherosclerosis...) : 1,25 ( OH ) 2D3 downregulation of c-Jun N-terminal kinase activation reduced PPARgamma and CD36 expression, and prevented oxLDL derived cholesterol uptake