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PPARG — RELA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Uchimura et al., Hepatology 2001
:
PPAR gamma:RXR activation also did not
affect nuclear factor kappa B (NF-kappa B) nuclear translocation nor
NF-kappa B and activator protein 1 (AP-1) activation in the electrophoretic mobility-shift assay ... Finally,
PPAR gamma:RXR activation
suppressed the LPS induced promoter activity of the
NF-kappa B-luciferase reporter gene in RAW 264.7 cells
Fahmi et al., Arthritis Rheum 2001
:
Similarly, in a
PPARgamma dependent manner, 15d-PGJ2 inhibited deltaMEKK-1 induced AP-1- and
NF-kappaB-luciferase reporter plasmid activation
Ji et al., J Autoimmun 2001
(Arthritis, Rheumatoid...) :
The
effect of
PPAR-gamma on the
nuclear factor (NF)-kappaB activity was tested by electrophoretic mobility shift assay ( EMSA )
Wayman et al., FASEB J 2002
(Myocardial Infarction...) :
The mechanisms of the cardioprotective effects of 15D-PGJ2 may include 1 ) activation of PPAR-alpha, 2 )
activation of
PPAR-gamma , 3 ) expression of HO-1, and 4 ) inhibition of the activation of
NF-kappaB in the ischemic reperfused heart
Wang et al., J Biol Chem 2002
(Inflammation) :
Furthermore, constitutive activation of
PPAR-gamma resulted in simultaneous repression of AP-1 and
NF-kappaB activity, which suggests that PPAR-gamma may reduce pro-inflammatory phenotypes via, at least in part, suppression of the AP-1 and NF-kappaB pathways
Ares et al., BMC immunology 2002
:
In contrast, oxidized LDL stimulated AP-1 and
PPARgamma but
inhibited NF-kappaB , indicating that the effects of lipid loading with ac-LDL were not due to oxidation of lipids
Suzawa et al., Nat Cell Biol 2003
:
Unlike suppression of the PPAR-gamma transactivation function by mitogen activated protein kinase induced growth factor signalling through phosphorylation of the A/B domain,
NF-kappaB blocks
PPAR-gamma binding to DNA by forming a complex with PPAR-gamma and its AF-1-specific co-activator PGC-2
Gately et al., Prog Exp Tumor Res 2003
(Neoplasms...) :
Some of the COX independent mechanisms for NSAIDs and selective COX-2 inhibitors include activation of protein kinase G, inhibition of
NF-kappa B activation, downregulation of the antiapoptotic protein Bcl-XL, inhibition of PPAR delta, and
activation of
PPAR gamma
Okano et al., Lab Invest 2003
(Carcinoma, Hepatocellular...) :
Although cell toxicity was induced when
PPARgamma was down-regulated in HepG2 cells,
NF-kappaB suppression and XIAP down-regulation were not
induced ... In SK-Hep1 cells, the ability of 15d-PGJ ( 2 ) to induce cell toxicity, NF-kappaB suppression, or XIAP down-regulation seemed to occur via a PPARgamma independent mechanism, but in HepG2 cells,
NF-kappaB suppression by 15d-PGJ ( 2 ) was
dependent on
PPARgamma
Dehmer et al., J Neurochem 2004
(Disease Models, Animal...) :
Because an increase in inhibitory protein-kappa-Balpha ( IkappaBalpha ) expression and inhibition of translocation of the nuclear factor kappaB (NFkappaB) subunit p65 to the nucleus in dopaminergic neurons, glial cells and astrocytes correlated with the protective effects of pioglitazone, our results suggest that pioglitazone sequentially acts through
PPARgamma activation , IkappaBalpha induction, block of
NFkappaB activation, iNOS induction and NO-mediated toxicity
Li et al., Kidney Int 2005
(Inflammation) :
Overexpression of
PPAR-gamma further
inhibited NF-kappaB activation compared to the control cells in the presence of EPA and DHA
Keshamouni et al., Neoplasia (New York, N.Y.) 2005
(Carcinoma, Non-Small-Cell Lung...) :
Furthermore,
PPAR-gamma activation
inhibited NF-kappa B transcriptional activity, as assessed by TransAM reporter gene assay
Kaplan et al., Shock 2005
(Lung Injury...) :
These inflammatory events were associated with reduced expression of
PPARgamma and with
activation of
nuclear factor-kappaB (NF-kappaB) in the lung
Konstantinopoulos et al., Int J Colorectal Dis 2007
(Adenocarcinoma...) :
Down-regulation of
PPAR gamma and induction of the CBP transcriptional coactivator can
augment NF-kappaB and AP-1 transcriptional activities leading to up-regulation of COX-2 expression in colon adenocarcinoma cells
Moulin et al., Biorheology 2006
:
The inhibitory potency of 15d-PGJ2 was unaffected by changes in
PPARgamma expression and
resulted from inhibition of
NF-kappaB nuclear binding and IkappaBalpha sparing, secondary to reduced phosphorylation of IKKbeta
von Knethen et al., J Cell Biol 2007
:
In these cells, we observed
PPARgamma dependent inhibition of
nuclear factor-kappaB (NF-kappaB) activation and TNF-alpha expression in response to PMA
Kaplan et al., Shock 2007
:
Overexpression of a dominant negative
PPARgamma mutant
prevented the inhibitory effect of ciglitazone on cytokine induced
NFkappaB activation in transfected human endothelial cells
Takada et al., Ann N Y Acad Sci 2007
:
One signaling is a TAK1/TAB1/NIK cascade activated by TNF-alpha and IL-1, and the activated
NF-kappaB blocked the DNA binding of
PPAR-gamma , attenuating the activated PPAR mediated adipogenesis
Yin et al., Pediatr Transplant 2008
(Vascular Diseases) :
Our results demonstrated that fish oil might attenuate CAV development, possibly through activating
PPAR gamma and subsequently
inhibiting the
NF-kappaB activation, the chemokines secretion, as well as the CCR2 expression
Wan et al., Biomed Pharmacother 2008
:
These findings provide evidence for the
involvement of the nuclear hormone receptors
PPARgamma in the activity of
NFkappaB in cerulein treated AR42J cells
Zand et al., Mol Cell Biochem 2008
:
Pretreatment of Ramos cells with GW9662 abrogated the ability of DHA to inhibit Gamma-IR induced activation of NF-kappaB and diminished the DHA radiosensitizing effect indicating that
PPAR-gamma may
act as a mediator of DHA in inhibition of
NF-kappaB ... Pretreatment of Ramos cells with GW9662 abrogated the ability of DHA to inhibit Gamma-IR induced activation of NF-kappaB and diminished the DHA radiosensitizing effect indicating that
PPAR-gamma may
act as a mediator of DHA in inhibition of
NF-kappaB
Wang et al., Zhonghua Jie He He Hu Xi Za Zhi 2008
(Acute Lung Injury) :
PPAR-gamma agonist ( troglitazone ) decreased the expression levels of inflammatory mediators such as TNF-alpha, reduced infiltration and activation of inflammatory cells in lung tissues, and alleviated LPS induced through
PPAR-gamma upregulation and
inhibition of
NF-kappaB activity
Shapiro et al., Nutr Res Rev 2005
:
The polyphenolic compound curcumin exhibits antioxidant and anti-inflammatory properties,
inhibits NF-kappaB and activates
PPAR-gamma
Baregamian et al., Biochem Biophys Res Commun 2009
(Enterocolitis, Necrotizing...) :
I/R injury resulted in early induction of
PPAR-gamma expression and
activation of
NF-kappaB in small intestine
Suliburk et al., Am J Physiol Gastrointest Liver Physiol 2009
(Drug-Induced Liver Injury...) :
Although CO abolished the ability of LPS to diminish
PPAR-gamma activity, it
enhanced NF-kappaB activity
Remels et al., Am J Physiol Endocrinol Metab 2009
:
Using C ( 2 ) C ( 12 ) myotubes as an in vitro model of myofibers, we demonstrate that PPAR, and specifically
PPARgamma , activation potently
inhibits inflammatory mediator induced
NF-kappaB transcriptional activity in a time- and dose dependent manner ... To verify whether muscular
NF-kappaB activity in human subjects is
suppressed by
PPARgamma activation, we examined the effect of 8 wk of rosiglitazone treatment on muscular gene expression of ICAM-1 and IL-8 in type 2 diabetes mellitus patients
Kim et al., J Mol Biol 2010
(Fatty Liver) :
HBx enhanced transcriptional activities of SREBP1 and
PPAR gamma are significantly
attenuated by the
NF-kappaB inhibitor Bay 11-7082, as well as by TNFR1 depletion
Biyashev et al., J Biol Chem 2010
(MAP Kinase Signaling System) :
PPARgamma , in turn is
critical for
NFkappaB activation, PEDF dependent apoptosis, and anti-angiogenesis
Tamai et al., Lab Invest 2010
:
Conversely, treatment of adipocytes with a PPARgamma antagonist enhanced NF-kappaB activation and conferred resistance to TNF-alpha induced apoptosis, suggesting
involvement of
PPARgamma in the suppression of
NF-kappaB in adipocytes
Kutsenko et al., FiziolohichnyÄ zhurnal (Kiev, Ukraine : 1994) 2012
:
Our results indicate for the
involvement of
PPAR-gamma in the regulation of
NF-kB activity which plays one of the most significant roles in the inflammation realization, oncogenesis, and so on