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AKT2 — PPP2R1A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Yung et al., J Neurochem 2003
:
The
PP1/PP2A phosphatase inhibitors okadaic acid and caliculyn A, but not cyclosporine A,
delayed the removal of ERK and
Akt phosphorylation under OGD
Li et al., Mol Cell Biol 2003
(Prostatic Neoplasms) :
Analysis of potential substrates for PP1 and PP2A revealed that cav-1 mediated inhibition of PP1 and
PP2A leads to increased PDK1,
Akt , and ERK1/2 activities
Zuluaga et al., Cell Signal 2007
:
Negative regulation of
Akt activity by p38alpha MAP kinase in cardiomyocytes
involves membrane localization of
PP2A through interaction with caveolin-1
Ni et al., Proc Natl Acad Sci U S A 2007
(Insulin Resistance) :
Repression of
Akt-PP2A/B interactions and phosphatase activities
contributes , at least in part, to FoxO dependent increases in
Akt phosphorylation and kinase activity
Guénin et al., Int J Oncol 2008
(Melanoma, Experimental) :
Protein
phosphatase 2A (PP2A) , an
Akt pathway
inhibitor , is considered to be activated by methylation of its catalytic subunit ... In untreated cells, okadaic acid, an antagonist of PP2A methylation,
inhibited PP2A activity, stimulated cell proliferation, increased
Akt activation and c-Myc expression
Modak et al., Biochem Biophys Res Commun 2008
(Breast Neoplasms) :
Here we propose that, rather than inhibiting PTEN function, CKIepsilon positively
regulates Akt possibly by inhibiting Protein
Phosphatase 2A (PP2A)
Jun et al., Obesity (Silver Spring) 2008
(Disease Models, Animal...) :
These data suggest that HFD might have a relevance to insulin resistance by increasing the expression of
PP2A , an
inhibitor of
AKT activity in the phosphatidylinositol 3-kinase (PI3K)/AKT pathway, and also by suppressing the expression of TC10 and CIP4, downstream effectors of the Cbl/CAP/TC10 insulin signaling cascade in the visceral adipose tissue
Hong et al., J Biol Chem 2008
:
A novel
Epac-Rap-PP2A signaling module
controls cAMP dependent
Akt regulation ... Here we show that ( i ) upstream regulators, PIK and PDK1, are not the target ( s ) of the cAMP inhibitory action ; ( ii ) constitutively active
Akt and calyculin A-stimulated Akt are resistant to cAMP inhibition, suggesting the action of a phosphatase ; ( iii ) cAMP increases the rate of Akt dephosphorylation, directly implicating an Akt-phosphatase ; ( iv ) Epac- and protein kinase A (PKA)-specific analogs synergistically inhibit Akt, indicating the involvement of both cAMP dependent effector pathways ; ( v ) H89 and dominant negative Epac 279E block cAMP-inhibitory action ; ( vi ) Epac associates in a complex with Akt and PP2A, and the associated-phosphatase activity is positively modulated by cAMP in a PKA- and Rap1 dependent manner ; ( vii ) like its action on Akt inhibition, PKA- and Epac-specific analogs synergistically
activate Epac associated
PP2A ; and ( viii ) dominant negative PP2A blocks cAMP-inhibitory action
Chan et al., Cell Biol Int 2009
:
Collectively, these findings suggest that
PP2A and PTEN may be
involved in fine tuning the regulation of
Akt/tuberin/mTOR/p70S6K in PC12 cells by M ( 4 ) mAChR and TrkA, respectively
Cao et al., Free Radic Biol Med 2009
(Leukemia) :
Further experiments indicate that the conformational change in
Akt not only disrupts Akt-Hsp90 binding, but also
enhances Akt-PP2A interaction
Switzer et al., Oncogene 2009
(Breast Neoplasms...) :
Dithiolethione compounds
inhibit Akt signaling in human breast and lung cancer cells by increasing
PP2A activity
O'Shaughnessy et al., Development 2009
:
Akt dependent
Pp2a activity is required for epidermal barrier formation during late embryonic development ... We therefore describe a novel
Akt dependent
Pp2a activity that acts at least partly through Jun to affect initial barrier formation during late embryonic epidermal development
Werden et al., J Virol 2010
(Neoplasms) :
In contrast, the
PP2A-specific phosphatase inhibitor okadaic acid
promoted increased
Akt kinase activation and rescued MYXV replication in human cancer cells that did not previously support viral replication
Switzer et al., Oncogene 2011
(Neoplasms) :
COG112 mediated increases in
PP2A activity
resulted in the inhibition of
Akt signaling and cellular proliferation
Galbo et al., PloS one 2011
(Insulin Resistance) :
Furthermore, inhibition of
PP2A by specific inhibitors
increased insulin stimulated activation of
Akt and phosphorylation of FoxO1 and Gsk3a
Chang et al., PloS one 2012
(Colonic Neoplasms) :
Our results indicate that epirubicin decreased the intracellular ROS in GRP78 knockdown cells, which decreased survival signaling through both the
Akt pathway and the
activation of
PP2A
Zhang et al., Diabetes 2012
(Hypertension...) :
We conclude that ceramide mediates obesity related vascular dysfunction by a mechanism that involves
PP2A mediated disruption of the
eNOS/Akt/Hsp90 signaling complex
Chen et al., Bioorg Med Chem 2012
:
Several studies have shown that downregulation of CIP2A by small molecules reduces
PP2A dependent phosphorylation of
Akt and induces cell death
Li et al., J Biol Chem 2013
:
Collectively these results suggest that rapamycin induces
PP2A dependent and DNA-PK mediated
Akt phosphorylation
Leonard et al., Cell cycle (Georgetown, Tex.) 2013
:
Inhibition of
Akt activation with MK2206
reduced the whole-cell and
centrosome levels of PLK-1 and ?-tubulin and also prevented the recruitment of PTEN to mitotic centrosomes
Kobayashi et al., Br J Pharmacol 2013
:
The inhibition of
Akt phosphorylation by SOL was
due to increased
PP2A phosphatase activity, which was reduced in COPD and oxidative stress model