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CAPN2 — PRKACG
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Shiraha et al., Mol Cell Biol 2002
:
EGF induced
calpain activation was
inhibited by cAMP activation of
protein kinase A (PKA) , as the PKA inhibitors H-89 and Rp-8Br-cAMPS abrogated cAMP inhibition of both motility and calpain activation
Bodnar et al., Circ Res 2006
:
Previous work showed that CXCR3 ligandation initiates
protein kinase A (PKA) phosphorylation dependent
inhibition of
m-calpain , required for induced cell motility, in fibroblasts but not epithelial cells ... Previous work showed that CXCR3 ligandation initiates
protein kinase A (PKA) phosphorylation dependent
inhibition of
m-calpain , required for induced cell motility, in fibroblasts but not epithelial cells ... These data indicate that the activation of CXCR3 inhibits endothelial tube formation through a
PKA mediated
inhibition of
m-calpain
Yan et al., Zhonghua Xue Ye Xue Za Zhi 2009
:
The actin binding protein (ABP) and talin proteolysis demonstrated that
calpain was
activated by
PKA inhibitor and expressed on the platelet membrane
Yates-Binder et al., PloS one 2012
:
Inhibition of endothelial function by IP-10p was similar to that described for IP-10, secondary to CXCR3 mediated increase in cAMP production,
activation of
PKA inhibiting cell migration, and inhibition of VEGF mediated
m-calpain activation
Queiroz et al., PloS one 2012
(Leukemia) :
Pro-death activity of violacein is actually carried out by inhibition of
calpain and DAPK1 and
activation of
PKA , AKT and PDK, followed by structural changes caused by endoplasmic reticulum stress and Golgi apparatus collapse, leading to cellular demise
Shell et al., Biochim Biophys Acta 2013
:
In the process of validating this assay, we discovered that
PKA activity is
regulated by the protease
calpain