Gene interactions and pathways from curated databases and text-mining

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CDKN1A — PRL

Text-mined interactions from Literome

Wu et al., Cancer Res 2005 (MAP Kinase Signaling System...) : S179D prolactin increases vitamin D receptor and p21 through up-regulation of short 1b prolactin receptor in human prostate cancer cells ... Blockade of ERK signaling eliminated S179D PRL stimulated expression of the VDR and p21 in LnCAP cells and transfected PC3 and DU145 cells
Wu et al., Oncol Res 2006 : S179D PRL , by contrast, had no effect on cyclin D1 and cdk4 expression, but increased p21 expression and expression of the vitamin D receptor (VDR)