◀ Back to WDR77
PRMT5 — WDR77
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Bind Interaction:
Complex of WDR77-ERH-STK38-POLR2B-PRMT5
Amente et al., FEBS Lett 2005
-
IRef Biogrid Interaction:
WDR77
—
PRMT5
(physical association, affinity chromatography technology)
Liu et al., Cancer Cell 2011*
-
IRef Biogrid Interaction:
WDR77
—
PRMT5
(direct interaction, pull down)
Hosohata et al., Mol Cell Biol 2003*
-
IRef Biogrid Interaction:
WDR77
—
PRMT5
(physical association, affinity chromatography technology)
Kristensen et al., Nat Methods 2012
-
IRef Biogrid Interaction:
WDR77
—
PRMT5
(physical association, affinity chromatography technology)
Patel et al., Mol Cell 2012*
-
IRef Biogrid Interaction:
WDR77
—
PRMT5
(direct interaction, two hybrid)
Hegele et al., Mol Cell 2012
-
IRef Biogrid Interaction:
WDR77
—
PRMT5
(association, biochemical)
Antonysamy et al., Proc Natl Acad Sci U S A 2012*
-
IRef Biogrid Interaction:
WDR77
—
PRMT5
(direct interaction, pull down)
Friesen et al., J Biol Chem 2002
-
IRef Biogrid Interaction:
WDR77
—
PRMT5
(physical association, affinity chromatography technology)
Friesen et al., J Biol Chem 2002
-
IRef Biogrid Interaction:
WDR77
—
PRMT5
(physical association, affinity chromatography technology)
Aggarwal et al., Cancer Cell 2010
-
MIPS CORUM AR coactivator complex:
AR coactivator complex complex (CLNS1A-PRMT5-WDR77)
Hosohata et al., Mol Cell Biol 2003*
-
MIPS CORUM FCP1-associated protein complex:
FCP1-associated protein complex complex (CTDP1-ERH-GTF2F1-POLR2B-PRMT5-STK38-WDR77)
Amente et al., FEBS Lett 2005
-
MIPS CORUM FCP1-associated protein complex:
FCP1-associated protein complex complex (CTDP1-ERH-GTF2F1-POLR2B-PRMT5-STK38-WDR77)
Licciardo et al., Nucleic Acids Res 2003
-
MIPS CORUM 20S methyltransferase complex:
20S methyltransferase complex complex (CLNS1A-PRMT5-WDR77)
Friesen et al., J Biol Chem 2002
-
IRef Corum Interaction:
Complex of WDR77-CLNS1A-PRMT5-WDR77-CLNS1A-PRMT5
(association, anti bait coimmunoprecipitation)
Friesen et al., J Biol Chem 2002
-
IRef Corum Interaction:
Complex of 15 proteins
(association, affinity chromatography technology)
Licciardo et al., Nucleic Acids Res 2003
-
IRef Dip Interaction:
Complex of 13 proteins
(anti tag coimmunoprecipitation)
Aygün et al., Proc Natl Acad Sci U S A 2008
-
IRef Dip Interaction:
WDR77
—
PRMT5
(direct interaction, anti tag coimmunoprecipitation)
Antonysamy et al., Proc Natl Acad Sci U S A 2012*
-
IRef Dip Interaction:
WDR77
—
PRMT5
(direct interaction, molecular sieving)
Antonysamy et al., Proc Natl Acad Sci U S A 2012*
-
IRef Dip Interaction:
WDR77
—
PRMT5
(direct interaction, cosedimentation in solution)
Antonysamy et al., Proc Natl Acad Sci U S A 2012*
-
IRef Hprd Interaction:
Complex of 23 proteins
(in vivo)
Ouararhni et al., Genes Dev 2006
-
IRef Hprd Interaction:
Complex of 507 proteins
(in vivo)
Ouararhni et al., Genes Dev 2006
-
IRef Hprd Interaction:
WDR77
—
PRMT5
(in vivo)
Friesen et al., J Biol Chem 2002
-
IRef Hprd Interaction:
WDR77
—
PRMT5
(in vitro)
Friesen et al., J Biol Chem 2002
-
IRef Intact Interaction:
Complex of WDR77-HIST1H4A-PRMT5-HIST1H4A-WDR77-PRMT5-HIST1H4A-WDR77-PRMT5
(methylation reaction, methyltransferase assay)
Aggarwal et al., Cancer Cell 2010
-
IRef Intact Interaction:
Complex of 76 proteins
(association, anti tag coimmunoprecipitation)
Weinmann et al., Cell 2009
-
IRef Intact Interaction:
Complex of 30 proteins
(association, anti tag coimmunoprecipitation)
Höck et al., EMBO Rep 2007
-
IRef Intact Interaction:
Complex of 43 proteins
(association, anti tag coimmunoprecipitation)
Weinmann et al., Cell 2009
-
IRef Intact Interaction:
Complex of 81 proteins
(association, anti tag coimmunoprecipitation)
Höck et al., EMBO Rep 2007
-
IRef Intact Interaction:
Complex of 13 proteins
(association, anti tag coimmunoprecipitation)
Pearce et al., Biochem J 2007
-
IRef Intact Interaction:
Complex of HNRNPH1-PLOD1-PRMT5-HNRNPA1-WDR77
(physical association, tandem affinity purification)
Hutchins et al., Science 2010
-
IRef Intact Interaction:
Complex of PRMT5-WDR77
(association, anti tag coimmunoprecipitation)
Aggarwal et al., Cancer Cell 2010
-
IRef Intact Interaction:
WDR77
—
PRMT5
(physical association, two hybrid)
Hegele et al., Mol Cell 2012
-
IRef Intact Interaction:
Complex of 11 proteins
(association, anti bait coimmunoprecipitation)
Chari et al., Cell 2008
-
IRef Intact Interaction:
Complex of 11 proteins
(association, anti bait coimmunoprecipitation)
Aggarwal et al., Cancer Cell 2010
Text-mined interactions from Literome
Furuno et al., Biochem Biophys Res Commun 2006
:
We show that the
MEP50 binds histone H2A selectively among core histones, and
mediates transcriptional repression of protein arginine methyltransferase
PRMT5 , which is known to methylate H2A and H4
Ho et al., PloS one 2013
:
These data support a mechanism in which
MEP50 binds substrate and
stimulates PRMT5 activity modulated by substrate post-translational modifications