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BMP10 — PTEN

Text-mined interactions from Literome

Beck et al., Cancer Biol Ther 2007 (Colonic Neoplasms) : BMP induced PTEN suppression was mediated via the RAS/ERK pathway, as pharmacologic inhibition of RAS/ERK, or interference with protein function in the cytosol by DN-RAS prevented BMP induced growth promotion and changes in PTEN levels, as did treatment with noggin, a BMP ligand inhibitor
Mathieu et al., Mol Cell Neurosci 2008 : Silencing Smad5 with siRNA or treatment with Noggin, a BMP antagonist, demonstrated that upregulation of PTEN in NSPCs required BMP/Smad signaling and that this pathway regulated cell cycle exit of NSPCs
Jerde et al., Prostate 2011 : We also treated doxacyclin-inducible PTEN-C4-2B cells with BMP-4 and doxacyclin to determine the effect of BMP on growth and PTEN expression in conditions of increasing PTEN expression ... BMP signaling induces PTEN expression and sustains PTEN protein expression resulting in inhibition of prostate epithelial cell growth