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MAP3K7 — PTGS2

Text-mined interactions from Literome

Choi et al., J Environ Pathol Toxicol Oncol 2005 : NF-kB inducing kinase (NIK) and TGF-k activated kinase 1 (TAK1) , the upstream signaling molecules of NF-kB, are involved in the silica mediated COX-2 expression
Zhang et al., Inflammation 2010 (Inflammation) : These results suggest that resistin enhances COX-2 expression in mouse macrophage cells in a TAK1-IKK-NF-kappaB dependent manner and therefore plays a critical role in inflammatory processes
Klatt et al., Connect Tissue Res 2010 (Osteoarthritis) : TAK1 mediates the collagen-II dependent induction of the COX-2 gene and PGE2 release in primary human chondrocytes
Ridder et al., J Exp Med 2011 (Fever...) : In conclusion, we demonstrate that TAK1 in brain endothelial cells induces COX-2 , most likely by activating p38 MAPK and c-Jun, and is necessary for fever and sickness behavior