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FGF18 — PTPN11
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
FGF18
→
PTPN11
(indirect_complex)
Agazie et al., Oncogene 2003, Ahmed et al., Biochem J 2008, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998
-
Reactome Reaction:
FGF18
→
PTPN11
(reaction)
Wong et al., Proc Natl Acad Sci U S A 2002, Fong et al., J Biol Chem 2003, Agazie et al., Oncogene 2003, Ahmed et al., Biochem J 2008, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998
Text-mined interactions from Literome
Pan et al., Development 2008
:
Bud specific N-sulfation of heparan sulfate regulates
Shp2 dependent
FGF signaling during lacrimal gland induction
Hatanaka et al., PloS one 2012
:
Among protein tyrosine phosphatases (PTPs) known to be involved in the maintenance of the VE-cadherin complex, suppression of
FGF signaling
reduces SHP2 expression levels and SHP2/VE-cadherin interaction due to accelerated SHP2 protein degradation
Hadari et al., Mol Cell Biol 1998
:
FGF stimulation
induces tyrosine phosphorylation of
Shp2 , leading to the formation of a complex containing Grb2 and Sos1 molecules