Gene interactions and pathways from curated databases and text-mining

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CASP9 — PTX3

Text-mined interactions from Literome

Shang et al., Urology 2007 (Carcinoma, Renal Cell...) : DAC could enhance the PTX induced upregulation of caspase activity and antiproliferative effect to increase the fraction of cells in the sub-G1 and G2/M phase
Shin et al., Oncol Rep 2008 (Carcinoma, Hepatocellular...) : PTX-2 activated caspases ( caspase-3 , -8 and -9 ) and the blockade of caspase-3 activity by the caspase-3 inhibitor prevented the PTX-2 induced apoptosis in Hep3B cells
Shang et al., Cancer Lett 2009 (Prostatic Neoplasms) : DAC enhanced the PTX induced up-regulation of caspase activity and antiproliferative effect, resulting in an increase of cells in subG1 and G2/M phases
Mitra et al., Molecular vision 2011 (Retinal Neoplasms...) : PTX-NP-EpCAM had superior antiproliferation activity, increased arrested cell population at the G(2)-M phase, and increased activation of caspase-3 , followed by PARP cleavage in parallel with the induction of apoptosis
Yang et al., Int J Nanomedicine 2013 : In addition, the PTX-NPs markedly inhibited interleukin-6 secretion, increased caspase-8 , caspase-9, and caspase-3 expression, and induced apoptosis of tumor cells in the treated mice