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EGFR — PXN

Pathways - manually collected, often from reviews:

• Reactome Reaction: EGFR → PXN (reaction) Montagner et al., J Biol Chem 2005

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 23 proteins (association, anti bait coimmunoprecipitation) Thelemann et al., Mol Cell Proteomics 2005
• IRef Intact Interaction: Complex of 70 proteins (association, anti bait coimmunoprecipitation) Thelemann et al., Mol Cell Proteomics 2005

Text-mined interactions from Literome

Salazar et al., J Cell Physiol 2003 : The experiments presented here were designed to test the role of epidermal growth factor receptor (EGFR) transactivation in the rapid increase of tyrosine phosphorylation of FAK and paxillin induced by GPCR agonists
Marcoux et al., Cell Signal 2005 : We demonstrate here that integrin dependent EGFR activation is also essential for adhesion induced formation of actin stress fibers, focal adhesion localization and tyrosine phosphorylation of the adapter protein paxillin , as well as transcriptional activation of the serum response factor
Sen et al., J Biol Chem 2010 (MAP Kinase Signaling System...) : Furthermore, EGFR induced Erk activation requires Src mediated phosphorylation of paxillin on tyrosines 31/118