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CRKL — RAC1

Pathways - manually collected, often from reviews:

• BioCarta links between pyk2 and map kinases: PYK2/SRC/P130cas/CRKL complex (PTK2B-SRC-BCAR1-CRKL) → RAC1 (modification, activates)
• BioCarta angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling: PYK2/SRC/P130cas/CRKL complex (PTK2B-SRC-BCAR1-CRKL) → RAC1 (modification, activates)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 177 proteins (association, cross-linking study) Byron et al., Proteomics 2012

Text-mined interactions from Literome

Li et al., Mol Cell Biol 2003 : Forced localization of CRKL to FAs ( FA-CRKL ) by itself was sufficient to induce activation of Rac1 and Cdc42 and rescued haptotaxis defects of mouse embryonic fibroblasts ( MEFs ) lacking Src, Yes, and Fyn, three broadly expressed Src family members required for integrin induced migration
Antoku et al., J Cell Sci 2009 : CrkII and CrkL preferentially activate the small GTPase Rac1 , whereas variants lacking a functional C-terminal SH3 domain, including CrkI, preferentially activate Rap1