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RAC3 — RELA

Pathways - manually collected, often from reviews:

• KEGG Pancreatic cancer: RAC1/RAC2/RAC3 → NFKB1/RELA (protein-protein, activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RAC3 — RELA (physical association, affinity chromatography technology) Rubio et al., Oncogene 2006*

Text-mined interactions from Literome

Huttunen et al., J Biol Chem 1999 (Neuroblastoma) : In contrast, the activation of NF-kappaB is inhibited by dominant negative Ras but not Rac or Cdc42
Werbajh et al., FEBS Lett 2000 : Here we report a role for the nuclear receptor coactivator RAC3 , in modulating NF-kappa B transactivation
Cammarano et al., J Biol Chem 2001 : Here we show that although Dbl activation of NF kappa B requires Cdc42, Rac , and Rho, the different GTPases activate NF kappa B by different mechanisms
Wroblewski et al., J Cell Sci 2003 (Neoplasm Invasiveness) : RhoA acted through activation of both NF-kappaB and AP-1, whereas Rac activated NF-kappaB but not AP-1
Alvarado et al., Medicina (B Aires) 2011 : The treatment of HEK293 cells with TNF-a induced an increase in the protein levels of RAC3 and this was blocked by an NF-kB specific inhibitor, suggesting that this transcription factor is involved in the cytokine effect