Chen et al., Mol Endocrinol 2005
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Inhibition of the GSK-3beta activity in P4-treated uteri by the specific inhibitor, LiCl, reversed the nuclear accumulation of cyclin D1 and in doing so, caused pRB phosphorylation and the induction of downstream genes, proliferating cell nuclear antigen and Ki67
Kong et al., Acta Pharmacol Sin 2010
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Gs-Rb1 caused a 77.3 % +/-3.2 % reduction in the expression of GSK-3beta protein ( P < 0.001 ) and a significant increase of 1.182+/-0.007-fold ( P=0.0001 ) in p-Ser9-GSK-3beta compared with control group
Zhao et al., Zhongguo Ying Yong Sheng Li Xue Za Zhi 2010
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These observations indicated that NSCs which were cultured and induced in vitro can express GSK-3beta, CDK-5 and PP2A ; moreover Abeta ( 25-35 ) and ginsenoside Rb1 can regulate the expressions of GSK-3beta , CDK-5 and PP2A