Gene interactions and pathways from curated databases and text-mining

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LEP — RELA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Bouloumie et al., FASEB J 1999 (Arteriosclerosis) : NF-kappaB , another redox-sensitive transcription factor, was also activated by leptin stimulation in an oxidant dependent manner
Sitaraman et al., FASEB J 2004 (Colitis...) : In response to luminal leptin , model intestinal epithelia critically activate the NF-kappaB , a key signaling system to pro-inflammatory stimuli
Li et al., Diabetes 2005 : In HASMCs, leptin induced PKC, extracellular signal regulated kinase ( ERK ) 1/2, and nuclear factor-kappaB (NF-kappaB) activation and inhibition of these signaling pathways abrogated HASMC proliferation and MMP-2 expression induced by this hormone ... Treatment of HASMCs with metformin decreased leptin induced ROS production and activation of PKC, ERK1/2, and NF-kappaB
Tang et al., J Immunol 2007 : The binding of p65 and p50 to the NF-kappaB elements, as well as the recruitment of p300 and the enhancement of histone H3 and H4 acetylation on the IL-6 promoter was enhanced by leptin
Tong et al., Cell Signal 2008 (Arthritis, Rheumatoid...) : The binding of p65 to the NF-kappaB elements, as well as the recruitment of p300 and the enhancement of histone H3 acetylation on the IL-8 promoter was enhanced by leptin , which was inhibited by wortmannin, Akt inhibitor or IRS-1 siRNA
Kanda et al., Endocrinology 2008 : IL-1beta enhanced the transcriptional activity of NF-kappaB , whereas leptin enhanced STAT1 and STAT3 activity
Jang et al., J Biol Chem 2010 (Anorexia) : In addition, hypothalamic NF-kappaB was activated by leptin , an important anorexigenic hormone, and mediates leptin stimulated POMC transcription, indicating that hypothalamic NF-kappaB also serves as a downstream signaling pathway of leptin
Gonzalez-Perez et al., Cell Signal 2010 (Mammary Neoplasms, Experimental) : Deletion analysis of VEGF promoter and RNA knockdown shows that HIF-1alpha and NFkappaB are essentials for leptin regulation of VEGF
Shi et al., Diabetologia 2013 (Inflammation) : Finally, RELA binds to STAT3 and inhibits STAT3 mediated promoter activity, suggesting that RELA , possibly together with forkhead box containing protein 1 ( FOXO1 ), may prevent STAT3 mediated leptin activation of the Pomc promoter