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PTGS2 — REN

Text-mined interactions from Literome

Traynor et al., Am J Physiol 1999 : The finding that COX-2 is critically involved in macula densa control of renin secretion indicates that the COX-2 expressing epithelial cells in the tubuloglomerular contact area are a likely source of prostaglandins participating in the signaling pathway between the macula densa and renin producing granular cells
Harding et al., J Hypertens 2000 : Because of this discrete cortical localization, we hypothesized that COX-2 plays a role in the chronic stimulation of renin via the macula densa pathway
Cheng et al., American journal of physiology. Renal physiology 2001 : We and others have previously found that selective COX-2 inhibitors can inhibit renal renin production ( Cheng HF, Wang JL, Zhang MZ, Miyazaki Y, Ichikawa I, McKanna JA, and Harris RC
Harris et al., Curr Opin Nephrol Hypertens 2001 (Gastrointestinal Diseases) : Cyclooxygenase-2 regulates renin-angiotensin secretion, and thereby glomerular filtration rate and sodium homeostasis
Höcherl et al., Pflugers Arch 2001 : In summary, these findings, obtained when the renin system was activated by AT1 receptor blockade, indicate that Ang II is not required to stimulate COX-2 expression and that COX-2 activity is not required to stimulate renin expression
Deray et al., Presse Med 2001 (Acute Kidney Injury...) : The regulatory role of Cox-2 on renin production has been demonstrated in the macula densa
Reinalter et al., Kidney Int 2002 (Bartter Syndrome...) : This observation proves the stimulatory role of COX-2 on renin-secretion in salt-depletion in humans
Hartner et al., American journal of physiology. Renal physiology 2003 (Disease Models, Animal...) : We tested whether COX-2 is required to increase renin in renovascular hypertension ... We conclude that inhibition of COX-2 in established renovascular hypertension does not affect renin synthesis or release
Castrop et al., American journal of physiology. Renal physiology 2003 (Renal Artery Obstruction) : Because across-the-board data indicate that renin and cyclooxygenase-2 (COX-2) expression in the kidney cortex are regulated in parallel and because ANG II can inhibit COX-2 expression, the purpose of our study was to characterize a potential general inhibitory feedback of the renin-angiotensin system on renocortical COX-2 expression in vivo
Okumura et al., Hypertens Res 2002 (Hypertension...) : The COX-2 inhibitor caused no significant changes in MBP, plasma renin activity, or urinary excretion, suggesting that COX-2 made a lesser contribution in this model
Stubbe et al., Am J Physiol Regul Integr Comp Physiol 2003 : Cyclooxygenase-2 contributes to elevated renin in the early postnatal period in rats
Harris et al., J Hypertens Suppl 2002 (Kidney Diseases) : COX-2 expression increases in high-renin states ( salt restriction, angiotensin converting enzyme inhibition, renovascular hypertension ) and selective COX-2 inhibitors significantly decrease plasma renin levels, renal renin activity and mRNA expression
Paliege et al., American journal of physiology. Renal physiology 2004 : To further explore the role of nNOS and COX-2 in renin secretion, we determined plasma renin activity in mice deficient in nNOS or COX-2
Harris et al., Acta Physiol Scand 2004 : In isolated perfused glomerular preparations, renin release induced by macula densa perfusion with a low chloride solution was inhibited by a COX-2 inhibitor but not a COX-1 inhibitor
Jensen et al., Acta Physiol Scand 2004 : Studies with selective inhibitors of COX-2 and COX-2 null mice show that COX-2 activity stimulates renin secretion from JG-cells during postnatal kidney development and that lack of COX-2 activity leads to pathological change in cortical architecture and eventually to renal failure
Fujino et al., J Clin Invest 2004 (Genetic Predisposition to Disease...) : PGI2 is produced by COX-2 and a selective inhibitor of this enzyme, SC-58125, also significantly reduced the increases in plasma renin activity and renin mRNA expression in WT mice with renal artery stenosis, but these effects were absent in IP-/- mice
Stichtenoth et al., Kidney Int 2005 (Body Weight) : Effects of specific COX-2-inhibition on renin release and renal and systemic prostanoid synthesis in healthy volunteers ... Renin-release in healthy humans with normal salt intake is COX-2 dependent
Yabuki et al., Exp Anim 2006 (Diabetes Mellitus, Type 2...) : Neuronal nitric oxide synthase (nNOS) and cyclooxygenase-2 (COX-2) regulate the tubuloglomerular feedback ( TGF ) and renin-angiotensin system (RAS) in the kidney
Kim et al., American journal of physiology. Renal physiology 2007 : In conclusion, chronic absence of COX-2 reduces renin expression, release, and PRC and is associated with a reduced ability to alter PRC during acute stimulation regardless of the nature of the stimulus
Matzdorf et al., American journal of physiology. Renal physiology 2007 (Hypertension, Renovascular) : The role of cyclooxygenase 2 (COX-2) in the control of renin is still a matter of debate, since studies with COX-2-deficient mice or with COX-2 inhibitors produced conflicting findings ... These findings indicate that COX-2 inhibition attenuates renin secretion and renin gene expression stimulated by a variety of parameters in proportion to the lowering of basal renin activity, while it does not interfere with the different stimulatory mechanism per se
Wagner et al., Am J Physiol Regul Integr Comp Physiol 2007 : Increased expression of cyclooxygenase 2 contributes to aberrant renin production in connexin 40-deficient kidneys ... In Cx40-deficient kidneys, basal renin mRNA levels were increased two-fold relative to wt kidneys, and these elevated mRNA levels were reduced to levels of untreated wt mice by COX-2 inhibitors
Harris et al., Curr Opin Nephrol Hypertens 2008 (Kidney Diseases) : There are also indications that macula densa cyclooxygenase-2 expression may be regulated by the prorenin/renin receptor
Zhang et al., Hypertension 2009 : Because macula densa COX-2 stimulates renal renin expression, our current studies investigated dopamine regulation of renal renin release and synthesis in vivo ... These results suggest that dopamine predominantly inhibits renal renin expression and release by inhibiting macula densa COX-2 , but suppression of renal cortical COX-2 activity reveals a contrasting effect of dopamine to stimulate renal renin expression through activation of D1-like receptors
Mitchell et al., Placenta 1996 : Moreover, renin treatment of both decidual and amnion cells induced increased levels of PGHS-2 within 2 h. Collectively, these results indicate that renin can act directly, separately from the generation of angiotensin-I and II
Hartner et al., Hypertension 1998 (Hypertension, Renovascular) : Our data are consistent with a role for macula densa cyclooxygenase-2 in the regulation of renin in renovascular hypertension