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JAK2 — RENBP

Text-mined interactions from Literome

Huang et al., Biochem J 1999 : Regarding the JAK/STAT pathway, AGE ( 100 microgram/ml ) induced tyrosine phosphorylation of JAK2 ( but not JAK1, JAK3 or TYK2 ) at 15-60 min ; it also induced the tyrosine phosphorylation of STAT1 and STAT3 at 1-2 h and 0.5-4 h respectively ... Being a transcription factor, AGE also increased the DNA binding activities of STAT1 and STAT3 AG-490 ( a specific JAK2 inhibitor ) ( 5 microM ) inhibited tyrosine phosphorylation of JAK2 and the DNA binding activities of STAT1 and STAT3
Lee et al., J Cell Biochem 2004 : We concluded that AGE induced JAK2 to increase leptin while leptin induced JAK2 to increase CTGF induced mitogenesis and type I collagen protein expression in NRK-49F cells