◀ Back to PTGS2
PTGS2 — RENBP
Text-mined interactions from Literome
Lin et al., Eur J Pharmacol 2002
:
Taken together, our results suggest that activation of protein tyrosine kinase and p38 MAPK is involved in
AGE induced
cyclooxygenase-2 expression in RAW 264.7 macrophages
Locatelli et al., Nephrol Dial Transplant 2003
(Diabetes Complications...) :
New treatment strategies are under investigation, including inhibitors of
AGE formation, protein kinase C inhibitors, antioxidants, glycosaminoglycans, PPAR-gamma agonists and
COX-2 inhibitors
Nah et al., Rheumatology (Oxford) 2008
(MAP Kinase Signaling System...) :
Pre-treatment with soluble receptor for AGE ( sRAGE ) also reduced
AGE stimulated
COX-2 , iNOS and PGE ( 2 ), implicating the involvement of RAGE
Huang et al., Eur J Clin Invest 2009
(Osteoarthritis) :
AGE potently
induced COX-2-PGE ( 2 ) and iNOS-NO activation in porcine and human chondrocytes
Wu et al., Pharmacology 2013
:
Results : Cariporide significantly suppressed
AGE induced neointimal hyperplasia, vascular smooth muscle cell ( VSMC ) proliferation,
COX-2 , MMP-2 and MMP-9 expression