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CCND1 — RHO

Text-mined interactions from Literome

Lee et al., Mol Cell Biol 2000 (Cell Transformation, Neoplastic...) : Induction of cyclin D1 by NeuT involved Ras, Rac, Rho , extracellular signal regulated kinase, c-Jun N-terminal kinase, and p38, but not phosphatidylinositol 3-kinase
Liberto et al., Oncogene 2002 : Rho regulates p21 ( CIP1 ), cyclin D1 , and checkpoint control in mammary epithelial cells ... Our results demonstrate that Rho plays a fundamental role in promoting Ras dependent S phase entry in mammary epithelial cells, whether in response to normal or oncogenic signaling, and indicate that in cells expressing oncogenic Ras, the activation of Rho diminishes p21 ( CIP1 ) expression, increases cyclin D1 promoter activity, and uncouples DNA synthesis from mitosis
Roovers et al., Mol Cell Biol 2003 (MAP Kinase Signaling System) : Inhibition of either MLCK or Rho kinase blocked sustained ERK signaling, but only Rho kinase inhibition allowed for the induction of cyclin D1 and activation of cdk4 via Rac/Cdc42 ... Overall, our results indicate that Rho kinase dependent stress fiber formation is required for sustained activation of the MEK/ERK pathway and the mid-G ( 1 ) phase induction of cyclin D1 , but not for other aspects of cdk4 or cdk2 activation
Roovers et al., Dev Cell 2003 : Nuclear translocation of LIM kinase mediates Rho-Rho kinase regulation of cyclin D1 expression
Swant et al., J Biol Chem 2005 (Cell Transformation, Neoplastic...) : Rho GTPase dependent signaling is required for macrophage migration inhibitory factor mediated expression of cyclin D1
Sterpetti et al., Am J Physiol Gastrointest Liver Physiol 2006 (Carcinoma, Hepatocellular...) : Lbc stably transfected hepatocarcinoma cells exhibit increased proliferation and levels of ERK and cyclin D1 activation, which are blocked by a Rho inhibitor
Morikawa-Futamatsu et al., Life Sci 2006 (Adenoviridae Infections...) : HMG-CoA reductase inhibitor fluvastatin prevents angiotensin II-induced cardiac hypertrophy via Rho kinase and inhibition of cyclin D1 ... Specific Rho kinase inhibitor, Y-27632 inhibited angiotensin II-induced cardiomyocyte hypertrophy and increased cyclin D1
Watts et al., Respir Res 2006 (Pulmonary Fibrosis) : This potentially unravels new molecular targets for future anti-IPF strategies ; accordingly, Simvastatin inhibition of Rho mediated cyclin D1 expression in IPF fibroblasts merits further exploitation
Cerezo et al., Mol Cell Biol 2009 (Cell Transformation, Neoplastic) : Restoring Rho activity, which is downregulated after loss of Cav1, antagonizes Rac1 and prevents cyclin D1 accumulation after serum starvation or loss of adhesion
Nie et al., EMBO Rep 2009 : Our data thus indicate that GEF-H1 and ZONAB form a signalling module that mediates Rho regulated cyclin D1 promoter activation and expression