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NOX4 — RNF19A
Text-mined interactions from Literome
Tojo et al., J Hypertens 2005
(Hypertension, Renal) :
We hypothesized that
p38 MAPK inhibitor, FR167653, may
suppress NAD ( P ) H oxidase and its oxygen radical production and ameliorate renal damage in Dahl salt-sensitive rats with heart failure ( DSHF )
Sun et al., Biol Pharm Bull 2008
(Inflammation) :
Nicotinamide adenine dinucleotide phosphate (
NADPH ) oxidase dependent activation of phosphoinositide 3-kinase and
p38 mitogen activated protein kinase signal pathways is required for lipopolysaccharide induced microglial phagocytosis
Ben Mkaddem et al., Cell Death Differ 2010
(Reperfusion Injury) :
Silencing
NOX4 mRNA expression
impaired hypoxia induced activation of ASK1 and both JNK and
p38 , leading to the inhibition of ROS production and apoptosis in posthypoxic TLR4 expressing RTECs
Lee et al., Circ Res 2010
:
Induction of
Nox4 expression, intracellular ROS formation and macrophage cytotoxicity induced by OxLDL were
blocked by MEK1/2 inhibition, but not by inhibitors of
p38-MAPK ( mitogen activated protein kinase ), JNK ( Jun N-terminal kinase ), or JAK2 ( Janus kinase 2 )
Ushio-Fukai et al., J Biol Chem 1998
:
However, exogenous H2O2 activates only
p38MAPK ( 14-fold ), and diphenylene iodonium, an
NADH/NADPH oxidase inhibitor , attenuates angiotensin II-stimulated phosphorylation of p38MAPK, but not p42/44MAPK