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NOX4 — RNF19A

Text-mined interactions from Literome

Tojo et al., J Hypertens 2005 (Hypertension, Renal) : We hypothesized that p38 MAPK inhibitor, FR167653, may suppress NAD ( P ) H oxidase and its oxygen radical production and ameliorate renal damage in Dahl salt-sensitive rats with heart failure ( DSHF )
Sun et al., Biol Pharm Bull 2008 (Inflammation) : Nicotinamide adenine dinucleotide phosphate ( NADPH ) oxidase dependent activation of phosphoinositide 3-kinase and p38 mitogen activated protein kinase signal pathways is required for lipopolysaccharide induced microglial phagocytosis
Ben Mkaddem et al., Cell Death Differ 2010 (Reperfusion Injury) : Silencing NOX4 mRNA expression impaired hypoxia induced activation of ASK1 and both JNK and p38 , leading to the inhibition of ROS production and apoptosis in posthypoxic TLR4 expressing RTECs
Lee et al., Circ Res 2010 : Induction of Nox4 expression, intracellular ROS formation and macrophage cytotoxicity induced by OxLDL were blocked by MEK1/2 inhibition, but not by inhibitors of p38-MAPK ( mitogen activated protein kinase ), JNK ( Jun N-terminal kinase ), or JAK2 ( Janus kinase 2 )
Ushio-Fukai et al., J Biol Chem 1998 : However, exogenous H2O2 activates only p38MAPK ( 14-fold ), and diphenylene iodonium, an NADH/NADPH oxidase inhibitor , attenuates angiotensin II-stimulated phosphorylation of p38MAPK, but not p42/44MAPK