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EPHB2 — ROCK1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Zhao et al., Mol Pharmacol 2006
:
In summary, these results demonstrate that Src,
Rho/ROCK , and an intact cytoskeleton
contribute to overall
ERK1/2 activation in SDF-1 stimulated cells and are indispensable for nuclear translocation of ERK1/2 and activation of transcription factors
Meriane et al., Stem Cells 2006
(MAP Kinase Signaling System) :
Moreover, MMP- and
ROCK dependent molecular events are implicated in the
regulation of the S1P induced activation of
ERK
Chapados et al., Circ Res 2006
(Disease Progression...) :
Indeed, SMCs on denatured collagen possessed higher levels of RhoA activity than those on native collagen, and blocking RhoA or
ROCK activities
attenuated SMC spreading,
ERK1/2 activity, and TN-C expression in SMCs on denatured collagen
Samarakoon et al., J Mol Cell Cardiol 2008
:
Thus, two distinct pathways involving the
EGFR/pp60(c-src)/MEK-ERK pathway and
Rho/ROCK dependent SMAD2
activation are required for TGF-beta1 induced PAI-1 expression in VSMC
Mair et al., Br J Pharmacol 2008
(Anoxia...) :
ROCK inhibition ablated increased pulmonary remodelling and hypertension observed in SERT+ mice, and
ROCK1/2 protein levels were elevated in SERT+ PFs. ROCK inhibition also
reduced 5-HT stimulated proliferation by suppressing MEK stimulated
ERK phosphorylation
Khatiwala et al., J Bone Miner Res 2009
(MAP Kinase Signaling System) :
Inhibition of RhoA and
ROCK in MC3T3-E1 pre-osteoblasts cultured on substrates of varying compliance
reduced ERK activity, whereas constitutively active RhoA enhanced it
Shih et al., J Bone Miner Res 2011
(Mechanotransduction, Cellular) :
In addition, FAK affects osteogenic differentiation through ERK1/2, whereas
ROCK regulates both FAK and
ERK1/2
Chaturvedi et al., Am J Physiol Cell Physiol 2011
(MAP Kinase Signaling System...) :
RhoA, ROCK inhibition, or RhoA,
ROCK1 , ROCK2, mDia1, and FAK reduction by siRNA
blocked deformation induced nuclear
ERK phosphorylation without preventing ERK phosphorylation in the cytoplasmic protein fraction