Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Liu et al., Assay Drug Dev Technol 2011 (Cardiomegaly) : FK506 binding protein12.6 ( FKBP12.6 ) binds to the Ca ( 2+ ) release channel ryanodine receptor ( RyR2 ) in cardiomyocytes and stabilizes RyR2 to prevent premature sarcoplasmic reticulum Ca ( 2+ ) release
Gant et al., J Neurosci 2011 (Calcium Signaling) : In cardiomyocytes, FK506 binding protein 1b/12.6 ( FKBP1b ) binds and stabilizes RyR2 in the closed state, inhibiting RyR mediated Ca ( 2+ ) release
Chini et al., Anesthesiology 2000 : The ryanodine receptor is stabilized by its association with FK506 binding protein ... Data are discussed in relation to the role of the FK506 binding protein in modulating the effect of halothane on the ryanodine receptor and the development of malignant hyperthermia phenotype
Wehrens et al., Cell 2003 (Arrhythmias, Cardiac...) : The FK506 binding protein ( FKBP12.6 ) stabilizes RyR2 , preventing aberrant activation of the channel during the resting phase of the cardiac cycle