Selbach et al., EMBO J 2003
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We show here that CagA ( P-Tyr ) inhibits the catalytic activity of c-Src in vivo and in vitro
Naito et al., Gastroenterology 2006
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Because Csk inhibits SFK, CagA with greater Csk binding activity more strongly inhibited Src dependent CagA phosphorylation and more effectively attenuated induction of cell elongation caused by CagA-SHP-2 interaction
Kwok et al., Nature 2007
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This interaction triggers CagA delivery into target cells as well as activation of focal adhesion kinase and Src