◀ Back to HIF1A
HIF1A — SERPINE1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Li et al., Kidney Int 2005
(Anoxia) :
A dominant negative form of
HIF-1alpha significantly
suppressed PAI-1 transcription activity induced by hypoxia
Liao et al., FASEB J 2007
:
Further, the
induction of
PAI-1 by Egr-1,
HIF-1alpha , or C/EBPalpha was replicated in primary peritoneal macrophages
Segura et al., J Surg Res 2007
(Postoperative Complications...) :
In vitro siRNA mediated down-regulation of
HIF-1alpha , PAI-1 or their simultaneous delivery
resulted in a significant decrease of
PAI-1 protein activity ( at least P < 0.05 )
Lin et al., J Biol Chem 2008
(MAP Kinase Signaling System...) :
In conclusion, our data provide a detailed mechanism by which Cyr61 promoted gastric cancer cell invasive ability via an
HIF-1alpha dependent up-regulation of
PAI-1
Bove et al., J Biol Chem 2008
(Inflammation) :
Finally, NO-mediated inhibition of cell migration was associated with
HIF-1alpha dependent
induction of
PAI-1 and activation of p53, both negative regulators of epithelial cell migration
Zhu et al., Osteoarthritis Cartilage 2009
:
CHIP assay further confirmed that the induction of
PAI-1 involved the binding of
HIF-1alpha to the PAI-1 promoter, while the enhancement or silencing of HIF-1alpha did not affect the expression of urokinase type PA (uPA), tissue type PA (tPA) or uPA receptor (uPAR) ... Additionally, IL-1beta stimulated both
HIF-1alpha and PAI-1 in articular chondrocytes, and the IL-1beta mediated induction of
PAI-1 was
inhibited partly by HIF-1alpha silencing
Artman et al., Int J Radiat Oncol Biol Phys 2010
(Carcinoma, Squamous Cell...) :
Downregulation of TGF-beta1 significantly decreased VEGF secretion in radiation-sensitive XF354 cells, and downregulation of
HIF-1alpha and HIF-2alpha
reduced PAI-1 and VEGF secretion in radiation-resistant SAS cells ... In addition, TGF-beta1 and
HIF-1alpha could be partly
responsible for VEGF and
PAI-1 upregulation after irradiation