Gene interactions and pathways from curated databases and text-mining

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AKT3 — SHH

Text-mined interactions from Literome

Riobó et al., Proc Natl Acad Sci U S A 2006 (Neoplasms) : Here, we report that phosphoinositide 3-kinase ( PI3-kinase ) -dependent Akt activation is essential for Sonic Hedgehog (Shh) signaling in the specification of neuronal fates in chicken neural explants, chondrogenic differentiation of 10T1/2 cells, and Gli activation in NIH 3T3 cells
Elia et al., Biochim Biophys Acta 2007 : Most importantly, we report that Shh induces MAPK/ERK and phosphoinositide 3-kinase (PI3K) dependent Akt phosphorylation and that activation of both signaling pathways is essential for Shh 's signaling in muscle cells ... However, the effect of Shh on Akt phosphorylation is more robust than that on MAPK/ERK, and data suggest that Shh influences these pathways in a manner similar to IGF-I ... By exploiting specific chemical inhibitors of the MAPK/ERK and PI3K/Akt signaling pathways, UO126 and Ly294002, respectively, we demonstrate that Shh induced Akt phosphorylation, but not that of MAPK/ERK, is required for its promotive effects on muscle cell proliferation and differentiation ... Taken together, we suggest that Shh acts in an autocrinic manner in adult myoblasts, and provide first evidence of a role for PI3K/Akt in Shh signaling during myoblast differentiation
Yang et al., J Hepatol 2008 : Adenoviral delivery of activated AKT up-regulated Shh expression, demonstrating a direct role for AKT in regulating Shh expression
Singh et al., J Biol Chem 2012 (Pancreatic Neoplasms) : CXCL12 induced SHH up-regulation is specifically mediated through the receptor CXCR4 and is dependent on the activation of downstream Akt and ERK signaling pathways
Li et al., Am J Physiol Heart Circ Physiol 2012 (Neointima) : Overexpression of wild-type mouse Shh through the tetracycline regulated expression-inducible system in human aortic SMCs time-dependently increased the levels of LC3-II and also stimulated protein kinase B ( AKT ) phosphorylation
Dai et al., J Huazhong Univ Sci Technolog Med Sci 2012 : The results showed that as compared with H ( 2 ) O ( 2 ) treatment, exogenous SHH could increase the expression of p-Akt by 20 % and decrease the expression of p-ERK by 33 %