Wheat et al., Am J Physiol Cell Physiol 2000
(Cystic Fibrosis) :
CFTR induces the expression of DRA along with Cl ( - ) /HCO ( 3 ) ( - ) exchange activity in tracheal epithelial cells ... In conclusion, CFTR induces the mRNA expression of "downregulated in adenoma '' ( DRA ) and, as a result, upregulates the apical Cl ( - ) /HCO ( 3 ) ( - ) exchanger activity in tracheal cells
Greeley et al., Am J Physiol Gastrointest Liver Physiol 2001
:
Downregulated in adenoma and putative anion transporter are regulated by CFTR in cultured pancreatic duct cells ... In conclusion, CFTR upregulates DRA and PAT1 expression in cultured pancreatic duct cells
Ko et al., EMBO J 2002
(Cystic Fibrosis) :
The physiological significance of these findings is demonstrated by interaction of CFTR and DRA in the mouse pancreas and an altered activation of DRA by the R117H and G551D mutants of CFTR
Ko et al., Nat Cell Biol 2004
(Cystic Fibrosis...) :
DRA markedly activates CFTR by increasing its overall open probablity ( NP ( o ) ) sixfold ... Activation of CFTR by DRA was facilitated by their PDZ ligands and binding of the SLC26T STAS domain to the CFTR R domain