UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to RBBP4

RBBP4 — SMAD4

Pathways - manually collected, often from reviews:

NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SKI/SIN3/HDAC complex/NCoR1 complex (SKI-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2) → SMAD3/SMAD4 complex (SMAD3-SMAD4) (modification, inhibits)
Luo et al., Genes Dev 1999, Akiyoshi et al., J Biol Chem 1999, Yahata et al., J Biol Chem 2000, Kim et al., Genes Dev 2000, Simonsson et al., J Biol Chem 2006, Tu et al., J Biol Chem 2007, Janknecht et al., Genes Dev 1998, Feng et al., Genes Dev 1998, Shioda et al., Proc Natl Acad Sci U S A 1998, Pouponnot et al., J Biol Chem 1998
Evidence: mutant phenotype, reporter gene, physical interaction
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: TGIF/SIN3/HDAC complex/CtBP complex (TGIF1-CTBP1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2) → SMAD2/SMAD2/SMAD4 complex (SMAD2-SMAD4) (modification, inhibits)
Wotton et al., Cell 1999, Yahata et al., J Biol Chem 2000, Melhuish et al., J Biol Chem 2000, Wotton et al., Cell Growth Differ 2001, Simonsson et al., J Biol Chem 2006, Tu et al., J Biol Chem 2007, Shioda et al., Proc Natl Acad Sci U S A 1998, Pouponnot et al., J Biol Chem 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SKI/SIN3/HDAC complex/NCoR1 complex (SKI-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2) → SMAD2/SMAD2/SMAD4 complex (SMAD2-SMAD4) (modification, inhibits)
Luo et al., Genes Dev 1999, Akiyoshi et al., J Biol Chem 1999, Yahata et al., J Biol Chem 2000, Simonsson et al., J Biol Chem 2006, Tu et al., J Biol Chem 2007, Shioda et al., Proc Natl Acad Sci U S A 1998, Pouponnot et al., J Biol Chem 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SnoN/SIN3/HDAC complex/NCoR1 complex (SKIL-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2) → SMAD2/SMAD2/SMAD4 complex (SMAD2-SMAD4) (modification, collaborate)
Stroschein et al., Science 1999
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SnoN/SIN3/HDAC complex/NCoR1 complex (SKIL-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2) → SMAD2/SMAD2/SMAD4/SnoN/SIN3/HDAC complex/NCoR1 complex (SMAD2-SMAD4-SKIL-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2) (modification, collaborate)
Stroschein et al., Science 1999
Evidence: mutant phenotype, physical interaction
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: SMAD2/SMAD2/SMAD4 complex (SMAD2-SMAD4) → SMAD2/SMAD2/SMAD4/SnoN/SIN3/HDAC complex/NCoR1 complex (SMAD2-SMAD4-SKIL-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2) (modification, collaborate)
Stroschein et al., Science 1999
Evidence: mutant phenotype, physical interaction