Fanayan et al., J Biol Chem 2000
(Breast Neoplasms) :
Phosphorylation of each Smad was stimulated by TGF-beta1 and, independently, by IGFBP-3 with the two agents together showing a cumulative effect
Ismail et al., Am J Physiol Lung Cell Mol Physiol 2009
:
Smad inhibition does not but the phosphatidylinositol 3-kinase (PI3K) signaling pathway inhibitor LY-294002 does inhibit NOX4 and IGFBP-3 gene expression, IGFBP-3 secretion, and cellular proliferation resulting from hypoxia
Zhong et al., J Cell Sci 2011
:
Biochemical assays and in vitro experiments revealed that IGFBP3 bound BMP2 and inhibited BMP2 induced Smad signaling in cultured human cells
de Silva et al., Endocrinology 2012
:
We conclude that IGFBP-3 activates inhibitory Smad signaling in 3T3-L1 cells and that endogenous IGFBP-3 modulates their adipogenic differentiation by regulating cell sensitivity towards the inhibitory effect of TGFß