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IGF1 — SMC3

Text-mined interactions from Literome

Myllärniemi et al., Cardiovasc Drugs Ther 1999 : Administration of the PDGF-R tyrosine kinase inhibitor in vivo, tested and found to inhibit the proliferation of SMC induced by PDGF-AA and PDGF-BB, but not by IGF-1 , EGF, or bFGF, resulted in a 60 % reduction in the absolute number and percentage of BrdU + cells after the second balloon injury to pre existing neointima, but had no significant effect on proliferation after the first injury
Ling et al., Mol Endocrinol 2003 : These results define a mechanism by which ligand occupancy of alphaVbeta3 regulates the SMC response to IGF-I
Resch et al., Endocrinology 2006 (Carotid Artery Injuries...) : In this study, we used mice with targeted disruption of the pregnancy associated plasma protein-A gene ( PAPP-A-/- ) and wild-type ( WT ) littermates to test the hypotheses that PAPP-A, a metalloproteinase that cleaves inhibitory IGF binding protein (IGFBP)-4, regulates vascular SMC responses to IGF-I in vitro and is critical for the development of vascular neointima after injury in vivo
Maile et al., Exp Diabetes Res 2010 (Hyperglycemia) : Furthermore we determined that TSP-1 also enhanced phosphorylation of the beta3 subunit of the alphaVbeta3 integrin, another molecular event that we have shown are critical for SMC response to IGF-I in high glucose
Bale et al., Am J Physiol Endocrinol Metab 2013 (Carotid Artery Injuries) : In this study, we used transgenic mice that constitutively express human PAPP-A in arterial smooth muscle to test the hypothesis that overexpression of PAPP-A enhances vascular smooth muscle cell ( SMC ) response to IGF-I in vivo
Dempsey et al., J Cell Physiol 1990 : This study investigates the potential proliferative effects of IGF-I on SMC cultured from the pulmonary arteries ( PA ) of neonatal calves
Gong et al., J Biol Chem 1995 : Epidermal growth factor (EGF) or insulin-like growth factor I (IGF-I) alone had little effect on SMC ScR activity
Tamaroglio et al., Exp Cell Res 1994 : IGF-I enhances SMC and FN mRNA levels, implying that acquisition of additional FN mRNA units accounts for the increase in FN levels
Yamamoto et al., Exp Cell Res 1994 : We examined the effects of platelet derived growth factor ( PDGF ), insulin-like growth factor-I (IGF-I) , and epidermal growth factor (EGF) on the regulation of SMC grown on type I collagen coated dishes in serum-free primary culture
Duan et al., J Biol Chem 1996 : Previous studies have shown that porcine aortic smooth muscle cells ( SMCs ) secrete two insulin-like growth factor binding proteins ( IGFBP ), IGFBP-2 and -4, and that these IGFBPs modulate IGF-I stimulated SMC proliferation and migration
Wang et al., Endocrinology 1998 : Although we can not exclude that the effects of IGFBP-4 may be IGF independent, these data suggest that IGFBP-4 is a functional antagonist of IGF-I action on SMC in vivo
Clemmons et al., Mol Cell Endocrinol 1998 : This event results in a potentiation of IGF-I action on fibroblasts and smooth muscle cells ( SMC )