Gene interactions and pathways from curated databases and text-mining

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SMG1 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Yamashita et al., Genes Dev 2001 : We also show that inhibitors of hSMG-1 induce the accumulation of truncated p53 proteins in human cancer cell lines with p53 PTC mutation
Brumbaugh et al., Mol Cell 2004 (Genomic Instability) : Expression of hSMG-1 is required for optimal p53 activation after cellular exposure to genotoxic stress, and depletion of hSMG-1 leads to spontaneous DNA damage and increased sensitivity to ionizing radiation ( IR )
Erker et al., Hum Mol Genet 2005 (Ataxia Telangiectasia...) : Inhibition of phosphoinositide 3-kinase (PI3K) family members suggested that SMG-1 was responsible for the tempol mediated enhancement of p53 serine 18 phosphorylation
Gehen et al., Oncogene 2008 (Hyperoxia) : Here, we show hSMG-1 is responsible for the rapid and early phosphorylation of p53 ( Ser15 ) and that ATM helps maintain phosphorylation after 24 h