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PDGFB — SMN1

Text-mined interactions from Literome

Kordes et al., Pancreas 2005 (MAP Kinase Signaling System) : In contrast, PDGF-BB reduced collagen type I in culture medium and synthesis of alpha-SMA
Yamate et al., Exp Toxicol Pathol 2005 (Fibrosis) : Moreover, PDGF-BB exhibited an additive effect on TGF-beta1 induced alpha-SMA expression in these cell lines when simultaneously added
Chen et al., J Biol Chem 2009 : Knockdown of FRS2 in VSMC by RNA interference inhibited PDGF-BB mediated down-regulation of SMA and SM22alpha without affecting PDGF-BB mediated cell proliferation or ERK activation
Bondi et al., J Am Soc Nephrol 2010 : The Smad3 inhibitor SIS3 reduced NADPH oxidase activity, Nox4 expression, and blocked alpha-SMA and Fn-ED-A, indicating that stimulation of myofibroblast activation by ROS is downstream of Smad3
Kuo et al., Planta Med 2012 : Results indicated that PDGF-BB increased migration as well as a-SMA and collagen expression in HSCs. Paeoniae Radix extracts and its active components, paeonol and 1,2,3,4,6-penta- O-galloyl- ß-D-glucose ( PGG ), inhibited PDGF-BB induced HSC migration and a-SMA and collagen expressions in a concentration dependent manner