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PTGS2 — SMPD2
Text-mined interactions from Literome
Ramer et al., Mol Pharmacol 2003
(Glioma) :
The involvement of ceramide in COX-2 expression was corroborated by findings showing that C2-ceramide and
neutral sphingomyelinase from Bacillus cereus
caused concentration dependent increases of
COX-2 expression that were suppressed in the presence of 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfonylphenyl ) -5- ( 4-pyridyl ) imidazol ( SB203580, a p38 MAPK inhibitor ) or 2'-amino-3'-methoxyflavone ( PD98059, a p42/44 MAPK activation inhibitor )
Chen et al., J Biol Chem 2009
:
Herein, we examined the
role of
neutral sphingomyelinase (nSMase)/ceramide in peptidoglycan ( PGN ) -induced NF-kappaB activation and
cyclooxygenase-2 (COX-2) expression in macrophages ... PGN induced
COX-2 expression was
attenuated by an
nSMase inhibitor ( 3-O-methyl-sphingomyeline, 3-OMS ) and ceramidase, but not by an acidic SMase inhibitor ( imipramine )