Gene interactions and pathways from curated databases and text-mining

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PTGS2 — SMPD2

Text-mined interactions from Literome

Ramer et al., Mol Pharmacol 2003 (Glioma) : The involvement of ceramide in COX-2 expression was corroborated by findings showing that C2-ceramide and neutral sphingomyelinase from Bacillus cereus caused concentration dependent increases of COX-2 expression that were suppressed in the presence of 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfonylphenyl ) -5- ( 4-pyridyl ) imidazol ( SB203580, a p38 MAPK inhibitor ) or 2'-amino-3'-methoxyflavone ( PD98059, a p42/44 MAPK activation inhibitor )
Chen et al., J Biol Chem 2009 : Herein, we examined the role of neutral sphingomyelinase (nSMase)/ceramide in peptidoglycan ( PGN ) -induced NF-kappaB activation and cyclooxygenase-2 (COX-2) expression in macrophages ... PGN induced COX-2 expression was attenuated by an nSMase inhibitor ( 3-O-methyl-sphingomyeline, 3-OMS ) and ceramidase, but not by an acidic SMase inhibitor ( imipramine )