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CSF3 — SOCS3
Text-mined interactions from Literome
Hörtner et al., J Immunol 2002
:
In this study, we demonstrate that human
SOCS-3 is rapidly
induced by
G-CSF in polymorphonuclear neutrophils as well as in the myeloid precursor cell line U937 and that SOCS-3 negatively regulates G-CSFR mediated STAT activation
Kimura et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
These data indicate that
SOCS3 negatively
regulates granulopoiesis and
G-CSF signaling in neutrophils and may contribute to neutrophilia or neutropenia
Nishiki et al., Am J Physiol Cell Physiol 2004
(MAP Kinase Signaling System) :
G-CSF mediated inhibition of LPS induced TNF-alpha production as well as G-CSF induced STAT3 phosphorylation and
suppressor of cytokine signaling 3 mRNA expression were prevented by pretreatment of monocytes with AG-490, an inhibitor of Janus kinase 2
van de Geijn et al., Blood 2004
(Disease Models, Animal...) :
SOCS3 efficiently
suppressed STAT3 and STAT5 activation by WT
G-CSF-R in luciferase reporter assays
van de Geijn et al., J Leukoc Biol 2004
:
In myeloid 32D cells, SOCS1 and
SOCS3 are
induced by
G-CSF
Kamezaki et al., Stem Cells 2005
:
In hematopoietic cells from Stat3-deficient mice, trace levels of
SOCS3 , a negative regulator of granulopoiesis, were observed, and SOCS3 expression was not
induced by
G-CSF stimulation
Irandoust et al., EMBO J 2007
:
Here, we show that a juxtamembrane lysine residue ( K632 ) of the granulocyte colony stimulating factor receptor ( G-CSFR ) plays a key role in receptor routing and demonstrate that the
effects of
SOCS3 on
G-CSF signaling to a major extent depend on this lysine
Boyle et al., J Reprod Immunol 2008
:
The creation of mice with conditional deletion of SOCS3 in different tissues has also uncovered critical
roles for
SOCS3 in the regulation of IL-6,
G-CSF and leptin signalling