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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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CSF3 — SOCS3

Text-mined interactions from Literome

Hörtner et al., J Immunol 2002 : In this study, we demonstrate that human SOCS-3 is rapidly induced by G-CSF in polymorphonuclear neutrophils as well as in the myeloid precursor cell line U937 and that SOCS-3 negatively regulates G-CSFR mediated STAT activation
Kimura et al., J Biol Chem 2004 (MAP Kinase Signaling System) : These data indicate that SOCS3 negatively regulates granulopoiesis and G-CSF signaling in neutrophils and may contribute to neutrophilia or neutropenia
Nishiki et al., Am J Physiol Cell Physiol 2004 (MAP Kinase Signaling System) : G-CSF mediated inhibition of LPS induced TNF-alpha production as well as G-CSF induced STAT3 phosphorylation and suppressor of cytokine signaling 3 mRNA expression were prevented by pretreatment of monocytes with AG-490, an inhibitor of Janus kinase 2
van de Geijn et al., Blood 2004 (Disease Models, Animal...) : SOCS3 efficiently suppressed STAT3 and STAT5 activation by WT G-CSF-R in luciferase reporter assays
van de Geijn et al., J Leukoc Biol 2004 : In myeloid 32D cells, SOCS1 and SOCS3 are induced by G-CSF
Kamezaki et al., Stem Cells 2005 : In hematopoietic cells from Stat3-deficient mice, trace levels of SOCS3 , a negative regulator of granulopoiesis, were observed, and SOCS3 expression was not induced by G-CSF stimulation
Irandoust et al., EMBO J 2007 : Here, we show that a juxtamembrane lysine residue ( K632 ) of the granulocyte colony stimulating factor receptor ( G-CSFR ) plays a key role in receptor routing and demonstrate that the effects of SOCS3 on G-CSF signaling to a major extent depend on this lysine
Boyle et al., J Reprod Immunol 2008 : The creation of mice with conditional deletion of SOCS3 in different tissues has also uncovered critical roles for SOCS3 in the regulation of IL-6, G-CSF and leptin signalling