Gene interactions and pathways from curated databases and text-mining

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SOD1 — SOD2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Gómez et al., Free radical research 1999 : The main chloroplastic SOD activity was due to CuZn-SOD II , which was increased significantly ( about 1.7-fold ) by NaCl, although during severe NaCl stress ( 110-130 mM ) chloroplastic Fe-SOD exhibited a stronger enhancement in its activity ( about 3.5-fold )
Wei et al., J Neurosci Res 2003 : We found that : ( 1 ) the decrease in cell viability induced by hydrogen peroxide was attenuated in PC12 cells pretreated with olanzapine ; ( 2 ) olanzapine increased SOD enzyme activity in PC12 cells ; ( 3 ) inhibiting SOD activity with diethyldithiocarbamic acid prevented the cytoprotective actions of olanzapine ; and ( 4 ) the decrease in SOD-1 mRNA level induced by hydrogen peroxide was blocked by pretreatment with olanzapine
Grzenkowicz-Wydra et al., Mol Cell Biochem 2004 : Overexpression of human SOD1 in mouse NIH 3T3 fibroblasts increased SOD activity, enhanced intracellular generation of H2O2 and significantly stimulated VEGF production as determined by increase in VEGF promoter activity, VEGF mRNA expression and VEGF protein synthesis
Smyth et al., Int J Exp Pathol 2009 (Drug-Induced Liver Injury) : In the dose response study, serum SOD activity was elevated in all CCl ( 4 ) -treated animals and urinary SOD-1 activity was increased 2.2 times at the lowest dose ( 0.10 ml/kg ) and 60.4 times at the highest CCl ( 4 ) dose level ( 0.80 ml/kg )
Greenough et al., J Biol Chem 2011 (Alzheimer Disease) : Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1 dependent copper/zinc superoxide dismutase activity
Giusti et al., Free radical research 2012 : Haplotypes reconstruction showed that SOD1 ( GG ) decreased the risk of RDS, IVH and ROP ; SOD2 ( GT ) increased the risk of BPD and decreased the risk of RDS, IVH and ROP ; SOD3 ( TGC ) decreased the risk of BPD and IVH ; and 4 ) CAT ( CTC ) decreased the risk of RDS ... Haplotypes reconstruction showed that SOD1 ( GG ) decreased the risk of RDS, IVH and ROP ; SOD2 ( GT ) increased the risk of BPD and decreased the risk of RDS, IVH and ROP ; SOD3 ( TGC ) decreased the risk of BPD and IVH ; and 4 ) CAT ( CTC ) decreased the risk of RDS ... Haplotypes reconstruction showed that SOD1 ( GG ) decreased the risk of RDS, IVH and ROP ; SOD2 ( GT ) increased the risk of BPD and decreased the risk of RDS, IVH and ROP ; SOD3 ( TGC ) decreased the risk of BPD and IVH ; and 4 ) CAT ( CTC ) decreased the risk of RDS
Poggi et al., The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2012 (Premature Birth) : Haplotypes reconstruction showed that SOD1 ( GG ) decreased the risk of RDS, IVH and ROP ; SOD2 ( GT ) increased the risk of BPD and decreased the risk of RDS, IVH, and ROP ; SOD3 ( TGC ) decreased the risk of BPD and IVH ; and CAT ( CTC ) decreased the risk of RDS ... Haplotypes reconstruction showed that SOD1 ( GG ) decreased the risk of RDS, IVH and ROP ; SOD2 ( GT ) increased the risk of BPD and decreased the risk of RDS, IVH, and ROP ; SOD3 ( TGC ) decreased the risk of BPD and IVH ; and CAT ( CTC ) decreased the risk of RDS
Yuan et al., Pflugers Arch 2013 (Hypertension) : However, SOD1 overexpression had no significant effect on the SOD2 activity in the PVN
Kim et al., Eur J Biochem 1996 : The presence of nickel at micromolar concentrations in growth media induced the expression of SOD1 ( nickel containing superoxide dismutase ; NiSOD ), whereas the expression of SOD2 ( iron/zinc containing superoxide dismutase ; FeZnSOD ) was repressed
Jerusalem et al., Neurology 1996 (Amyotrophic Lateral Sclerosis) : The involvement of superoxide dismutase in sporadic ALS is unclear