Gene interactions and pathways from curated databases and text-mining

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SOS1 — SRC

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Li et al., Am J Physiol Cell Physiol 2007 (MAP Kinase Signaling System) : ANG II induced a Src dependent association between Shc and growth factor receptor bound protein 2 ( Grb2 ) and between Grb2 and son of sevenless ( Sos ) , both of which were maximal at 15 min
Samoylenko et al., Carcinogenesis 2012 (Adenocarcinoma...) : Thereby, Ruk ( l ) /CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src , Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility