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SOX9 — TCF7
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes transcription factor complex:
transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3)
Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999
Text-mined interactions from Literome
Akiyama et al., Genes Dev 2004
:
We hypothesize that the inhibitory activity of
Sox9 is
caused by its ability to compete with
Tcf/Lef for binding to beta-catenin, followed by degradation of beta-catenin
Blache et al., J Cell Biol 2004
(Carcinoma...) :
We provide in vitro and in vivo evidence that a bipartite beta-catenin/TCF4
transcription factor , the effector of the Wnt signaling pathway, is
required for
SOX9 expression in epithelial cells
Hwang et al., FEBS Lett 2005
:
AP-1 activation suppressed the expression of
Sox-9 , a major
transcription factor regulating type II collagen expression
Bastide et al., J Cell Biol 2007
:
Sox9 expression
requires an active
beta-catenin-Tcf complex, the transcriptional effector of the Wnt pathway
Passeron et al., Proc Natl Acad Sci U S A 2007
:
During melanocyte development from the neural crest,
SOX10 regulates microphthalmia associated
transcription factor , which controls a set of genes critical for pigment cell development and pigmentation, including dopachrome tautomerase and tyrosinase ... In adult and neonatal melanocytes,
SOX9 regulates microphthalmia associated
transcription factor , dopachrome tautomerase, and tyrosinase promoters, leading to an increase in the expression of these key melanogenic proteins and finally to a stimulation of pigmentation
Chen et al., Liver Int 2013
(Carcinoma, Hepatocellular...) :
In addition,
SOX4 in HepG2 cell can
enhance ß-catenin/TCF activity by increasing ß-catenin level
Stöckl et al., J Cell Sci 2013
:
We found that the
Sox9 activity level
affects the expression of the key
transcription factor in adipogenic differentiation, C/EBPß, and that cyclin D1 mediates the expression of the osteogenic marker osteocalcin in undifferentiated adult bone-marrow derived rat MSC